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Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?

BACKGROUND: Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant. The angiotensin-converting enzyme (ACE) DD genotype is associated with raised AC...

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Autores principales: Harding, David R, Dhamrait, Sukhbir, Devadason, David, Humphries, Steve E, Whitelaw, Andrew, Marlow, Neil, Montgomery, Hugh E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC553995/
https://www.ncbi.nlm.nih.gov/pubmed/15725359
http://dx.doi.org/10.1186/1742-2094-2-6
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author Harding, David R
Dhamrait, Sukhbir
Devadason, David
Humphries, Steve E
Whitelaw, Andrew
Marlow, Neil
Montgomery, Hugh E
author_facet Harding, David R
Dhamrait, Sukhbir
Devadason, David
Humphries, Steve E
Whitelaw, Andrew
Marlow, Neil
Montgomery, Hugh E
author_sort Harding, David R
collection PubMed
description BACKGROUND: Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant. The angiotensin-converting enzyme (ACE) DD genotype is associated with raised ACE and RAS activity as well as potentially adverse stimuli such as inflammation. The DD genotype has been associated with neurological impairments in the elderly, and thus may be also associated with poorer motor or cognitive development amongst children born preterm prematurely. METHODS: The association of DD genotype with developmental progress amongst 176 Caucasian children born at less than 33 weeks gestation (median birthweight 1475 g, range 645–2480 g; gestation 30 weeks, range 22–32; 108 male) was examined at 2 and 5 1/2 years of age. Measured neuro-cognitive outcomes were cranial ultrasound abnormalities, cerebral palsy, disability, Griffiths Developmental Quotient [DQ] at 2 yrs, and General Cognitive Ability [British Ability Scales-11] and motor performance [ABC Movement], both performed at 5 1/2 yrs. All outcomes were correlated with ACE genotype. RESULTS: The DD genotype was not associated with lower developmental quotients even after accounting for important social variables. CONCLUSION: These data do not support either a role for ACE in the development of cognitive or motor function in surviving infants born preterm or inhibition of ACE as a neuroprotective therapy.
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spelling pubmed-5539952005-03-11 Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? Harding, David R Dhamrait, Sukhbir Devadason, David Humphries, Steve E Whitelaw, Andrew Marlow, Neil Montgomery, Hugh E J Neuroinflammation Research BACKGROUND: Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant. The angiotensin-converting enzyme (ACE) DD genotype is associated with raised ACE and RAS activity as well as potentially adverse stimuli such as inflammation. The DD genotype has been associated with neurological impairments in the elderly, and thus may be also associated with poorer motor or cognitive development amongst children born preterm prematurely. METHODS: The association of DD genotype with developmental progress amongst 176 Caucasian children born at less than 33 weeks gestation (median birthweight 1475 g, range 645–2480 g; gestation 30 weeks, range 22–32; 108 male) was examined at 2 and 5 1/2 years of age. Measured neuro-cognitive outcomes were cranial ultrasound abnormalities, cerebral palsy, disability, Griffiths Developmental Quotient [DQ] at 2 yrs, and General Cognitive Ability [British Ability Scales-11] and motor performance [ABC Movement], both performed at 5 1/2 yrs. All outcomes were correlated with ACE genotype. RESULTS: The DD genotype was not associated with lower developmental quotients even after accounting for important social variables. CONCLUSION: These data do not support either a role for ACE in the development of cognitive or motor function in surviving infants born preterm or inhibition of ACE as a neuroprotective therapy. BioMed Central 2005-02-22 /pmc/articles/PMC553995/ /pubmed/15725359 http://dx.doi.org/10.1186/1742-2094-2-6 Text en Copyright © 2005 Harding et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Harding, David R
Dhamrait, Sukhbir
Devadason, David
Humphries, Steve E
Whitelaw, Andrew
Marlow, Neil
Montgomery, Hugh E
Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?
title Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?
title_full Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?
title_fullStr Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?
title_full_unstemmed Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?
title_short Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?
title_sort does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC553995/
https://www.ncbi.nlm.nih.gov/pubmed/15725359
http://dx.doi.org/10.1186/1742-2094-2-6
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