Cargando…
Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B
BACKGROUND: The aim of this study was to investigate the feasibility of using acoustic radiation force impulse (ARFI) elastography, AST-to-platelet ratio index (APRI), and FIB-4 in assessing liver fibrosis and free portal pressure in patients with hepatitis B. MATERIAL/METHODS: We enrolled 126 patie...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540073/ https://www.ncbi.nlm.nih.gov/pubmed/28735336 http://dx.doi.org/10.12659/MSM.905896 |
_version_ | 1783254583109222400 |
---|---|
author | Li, Jun Yu, Jie Peng, Xin-Yu Du, Ting-Ting Wang, Jia-Jia Tong, Jin Lu, Gui-Lin Wu, Xiang-Wei |
author_facet | Li, Jun Yu, Jie Peng, Xin-Yu Du, Ting-Ting Wang, Jia-Jia Tong, Jin Lu, Gui-Lin Wu, Xiang-Wei |
author_sort | Li, Jun |
collection | PubMed |
description | BACKGROUND: The aim of this study was to investigate the feasibility of using acoustic radiation force impulse (ARFI) elastography, AST-to-platelet ratio index (APRI), and FIB-4 in assessing liver fibrosis and free portal pressure in patients with hepatitis B. MATERIAL/METHODS: We enrolled 126 patients with hepatitis B who underwent liver surgery at the General Surgery Department of the First Affiliated Hospital of Shihezi University Medical School from February 2013 to August 2015. Preoperatively, shear wave velocity (SWV) of the liver was measured with the Siemens S2000 ultrasound system to reflect liver stiffness. Serological markers were collected and fibrosis indices APRI and FIB-4 were calculated. Intraoperatively, liver tissues were harvested and free portal pressure (FPP) was measured. Postoperatively, fibrosis of liver tissues was pathologically staged. RESULTS: The results of SWV, APRI, FIB-4, and FPP were all correlated with the degree of liver fibrosis (Spearman correlation coefficients: r=0.777, P<0.001; r=0.526, P<0.001; r=0.471, P<0.001; p<0.000; r=0.675, p<0.000). Receiver operating characteristic curve (ROC) analysis showed that the areas under the curve (AUC) of ARFI, APRI, and FIB-4 in diagnosing liver fibrosis were 0.830, 0.768, and 0.717, respectively, for stage F≥1; 0.861, 0.773, and 0.754, respectively, for stage F≥2; 0.941, 0.793, and 0.779, respectively, for stage F≥3; and 0.945, 0.783, and 0.754, respectively, for stage F=4. SWV, APRI, and FIB-4 were all correlated with FPP (Pearson correlation coefficients: 0.387, P<0.001; 0.446, P<0.001; 0.419, P<0.001). CONCLUSIONS: ARFI, APRI, and FIB-4 can assess liver fibrosis in patients with hepatitis B when assessing the portal venous pressure. The difference in diagnostic efficacy between the 3 was not significant. |
format | Online Article Text |
id | pubmed-5540073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55400732017-08-15 Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B Li, Jun Yu, Jie Peng, Xin-Yu Du, Ting-Ting Wang, Jia-Jia Tong, Jin Lu, Gui-Lin Wu, Xiang-Wei Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to investigate the feasibility of using acoustic radiation force impulse (ARFI) elastography, AST-to-platelet ratio index (APRI), and FIB-4 in assessing liver fibrosis and free portal pressure in patients with hepatitis B. MATERIAL/METHODS: We enrolled 126 patients with hepatitis B who underwent liver surgery at the General Surgery Department of the First Affiliated Hospital of Shihezi University Medical School from February 2013 to August 2015. Preoperatively, shear wave velocity (SWV) of the liver was measured with the Siemens S2000 ultrasound system to reflect liver stiffness. Serological markers were collected and fibrosis indices APRI and FIB-4 were calculated. Intraoperatively, liver tissues were harvested and free portal pressure (FPP) was measured. Postoperatively, fibrosis of liver tissues was pathologically staged. RESULTS: The results of SWV, APRI, FIB-4, and FPP were all correlated with the degree of liver fibrosis (Spearman correlation coefficients: r=0.777, P<0.001; r=0.526, P<0.001; r=0.471, P<0.001; p<0.000; r=0.675, p<0.000). Receiver operating characteristic curve (ROC) analysis showed that the areas under the curve (AUC) of ARFI, APRI, and FIB-4 in diagnosing liver fibrosis were 0.830, 0.768, and 0.717, respectively, for stage F≥1; 0.861, 0.773, and 0.754, respectively, for stage F≥2; 0.941, 0.793, and 0.779, respectively, for stage F≥3; and 0.945, 0.783, and 0.754, respectively, for stage F=4. SWV, APRI, and FIB-4 were all correlated with FPP (Pearson correlation coefficients: 0.387, P<0.001; 0.446, P<0.001; 0.419, P<0.001). CONCLUSIONS: ARFI, APRI, and FIB-4 can assess liver fibrosis in patients with hepatitis B when assessing the portal venous pressure. The difference in diagnostic efficacy between the 3 was not significant. International Scientific Literature, Inc. 2017-07-23 /pmc/articles/PMC5540073/ /pubmed/28735336 http://dx.doi.org/10.12659/MSM.905896 Text en © Med Sci Monit, 2017 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Li, Jun Yu, Jie Peng, Xin-Yu Du, Ting-Ting Wang, Jia-Jia Tong, Jin Lu, Gui-Lin Wu, Xiang-Wei Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B |
title | Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B |
title_full | Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B |
title_fullStr | Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B |
title_full_unstemmed | Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B |
title_short | Acoustic Radiation Force Impulse (ARFI) Elastography and Serological Markers in Assessment of Liver Fibrosis and Free Portal Pressure in Patients with Hepatitis B |
title_sort | acoustic radiation force impulse (arfi) elastography and serological markers in assessment of liver fibrosis and free portal pressure in patients with hepatitis b |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540073/ https://www.ncbi.nlm.nih.gov/pubmed/28735336 http://dx.doi.org/10.12659/MSM.905896 |
work_keys_str_mv | AT lijun acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb AT yujie acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb AT pengxinyu acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb AT dutingting acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb AT wangjiajia acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb AT tongjin acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb AT luguilin acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb AT wuxiangwei acousticradiationforceimpulsearfielastographyandserologicalmarkersinassessmentofliverfibrosisandfreeportalpressureinpatientswithhepatitisb |