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Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates
Neural induction is the process through which pluripotent cells are committed to a neural fate. This first step of Central Nervous System formation is triggered by the "Spemann organizer" in amphibians and by homologous embryonic regions in other vertebrates. Studies in classical vertebrat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540175/ https://www.ncbi.nlm.nih.gov/pubmed/28782045 http://dx.doi.org/10.1038/s41559-017-0226-3 |
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author | Le Petillon, Yann Luxardi, Guillaume Scerbo, Pierluigi Cibois, Marie Leon, Anthony Subirana, Lucie Irimia, Manuel Kodjabachian, Laurent Escriva, Hector Bertrand, Stephanie |
author_facet | Le Petillon, Yann Luxardi, Guillaume Scerbo, Pierluigi Cibois, Marie Leon, Anthony Subirana, Lucie Irimia, Manuel Kodjabachian, Laurent Escriva, Hector Bertrand, Stephanie |
author_sort | Le Petillon, Yann |
collection | PubMed |
description | Neural induction is the process through which pluripotent cells are committed to a neural fate. This first step of Central Nervous System formation is triggered by the "Spemann organizer" in amphibians and by homologous embryonic regions in other vertebrates. Studies in classical vertebrate models have produced contrasting views about the molecular nature of neural inducers and no unifying scheme could be drawn. Moreover, how this process evolved in the chordate lineage remains an unresolved issue. In this work, by using graft and micromanipulation experiments, we definitively establish that the dorsal blastopore lip of the cephalochordate amphioxus is homologous to the vertebrate organizer and is able to trigger the formation of neural tissues in a host embryo. In addition, we demonstrate that Nodal/Activin is the main signal eliciting neural induction in amphioxus, and that it also functions as a bona fide neural inducer in the classical vertebrate model Xenopus. Altogether, our results allow us to propose that Nodal/Activin was a major player of neural induction in the ancestor of chordates. This study further reveals the diversity of neural inducers deployed during chordate evolution and advocates against a universally conserved molecular explanation for this process. |
format | Online Article Text |
id | pubmed-5540175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-55401752018-01-03 Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates Le Petillon, Yann Luxardi, Guillaume Scerbo, Pierluigi Cibois, Marie Leon, Anthony Subirana, Lucie Irimia, Manuel Kodjabachian, Laurent Escriva, Hector Bertrand, Stephanie Nat Ecol Evol Article Neural induction is the process through which pluripotent cells are committed to a neural fate. This first step of Central Nervous System formation is triggered by the "Spemann organizer" in amphibians and by homologous embryonic regions in other vertebrates. Studies in classical vertebrate models have produced contrasting views about the molecular nature of neural inducers and no unifying scheme could be drawn. Moreover, how this process evolved in the chordate lineage remains an unresolved issue. In this work, by using graft and micromanipulation experiments, we definitively establish that the dorsal blastopore lip of the cephalochordate amphioxus is homologous to the vertebrate organizer and is able to trigger the formation of neural tissues in a host embryo. In addition, we demonstrate that Nodal/Activin is the main signal eliciting neural induction in amphioxus, and that it also functions as a bona fide neural inducer in the classical vertebrate model Xenopus. Altogether, our results allow us to propose that Nodal/Activin was a major player of neural induction in the ancestor of chordates. This study further reveals the diversity of neural inducers deployed during chordate evolution and advocates against a universally conserved molecular explanation for this process. 2017-07-03 2017-08 /pmc/articles/PMC5540175/ /pubmed/28782045 http://dx.doi.org/10.1038/s41559-017-0226-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Le Petillon, Yann Luxardi, Guillaume Scerbo, Pierluigi Cibois, Marie Leon, Anthony Subirana, Lucie Irimia, Manuel Kodjabachian, Laurent Escriva, Hector Bertrand, Stephanie Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates |
title | Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates |
title_full | Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates |
title_fullStr | Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates |
title_full_unstemmed | Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates |
title_short | Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates |
title_sort | nodal/activin pathway is a conserved neural induction signal in chordates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540175/ https://www.ncbi.nlm.nih.gov/pubmed/28782045 http://dx.doi.org/10.1038/s41559-017-0226-3 |
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