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Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives

BACKGROUND: Ethiopia is endowed with abundant medicinal plant resources and traditional medicinal practices. However, available research evidence on indigenous anti-malarial plants is highly fragmented in the country. The present systematic review attempted to explore, synthesize and compile ethno-m...

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Autores principales: Alebie, Getachew, Urga, Befikadu, Worku, Amha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540187/
https://www.ncbi.nlm.nih.gov/pubmed/28764723
http://dx.doi.org/10.1186/s12936-017-1953-2
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author Alebie, Getachew
Urga, Befikadu
Worku, Amha
author_facet Alebie, Getachew
Urga, Befikadu
Worku, Amha
author_sort Alebie, Getachew
collection PubMed
description BACKGROUND: Ethiopia is endowed with abundant medicinal plant resources and traditional medicinal practices. However, available research evidence on indigenous anti-malarial plants is highly fragmented in the country. The present systematic review attempted to explore, synthesize and compile ethno-medicinal research evidence on anti-malarial medicinal plants in Ethiopia. METHODS: A systematic web search analysis and review was conducted on research literature pertaining to medicinal plants used for traditional malaria treatment in Ethiopia. Data were collected from a total of 82 Ethiopian studies meeting specific inclusion criteria including published research articles and unpublished thesis reports. SPSS Version 16 was used to summarize relevant ethno-botanical/medicinal information using descriptive statistics, frequency, percentage, tables, and bar graphs. RESULTS: A total of 200 different plant species (from 71 families) used for traditional malaria treatment were identified in different parts of Ethiopia. Distribution and usage pattern of anti-malarial plants showed substantial variability across different geographic settings. A higher diversity of anti-malarial plants was reported from western and southwestern parts of the country. Analysis of ethno-medicinal recipes indicated that mainly fresh leaves were used for preparation of remedies. Decoction, concoction and eating/chewing were found to be the most frequently employed herbal remedy preparation methods. Notably, anti-malarial herbal remedies were administered by oral route. Information on potential side effects of anti-malarial herbal preparations was patchy. However, some anti-malarial plants were reported to have potentially serious side effects using different local antidotes and some specific contra-indications. CONCLUSION: The study highlighted a rich diversity of indigenous anti-malarial medicinal plants with equally divergent herbal remedy preparation and use pattern in Ethiopia. Baseline information gaps were observed in key geographic settings. Likewise, herbal remedy toxicity risks and countermeasures generally entailed more exhaustive investigation. Experimental research and advanced chemical analysis are also required to validate the therapeutic potential of anti-malarial compounds from promising plant species. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12936-017-1953-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-55401872017-08-03 Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives Alebie, Getachew Urga, Befikadu Worku, Amha Malar J Review BACKGROUND: Ethiopia is endowed with abundant medicinal plant resources and traditional medicinal practices. However, available research evidence on indigenous anti-malarial plants is highly fragmented in the country. The present systematic review attempted to explore, synthesize and compile ethno-medicinal research evidence on anti-malarial medicinal plants in Ethiopia. METHODS: A systematic web search analysis and review was conducted on research literature pertaining to medicinal plants used for traditional malaria treatment in Ethiopia. Data were collected from a total of 82 Ethiopian studies meeting specific inclusion criteria including published research articles and unpublished thesis reports. SPSS Version 16 was used to summarize relevant ethno-botanical/medicinal information using descriptive statistics, frequency, percentage, tables, and bar graphs. RESULTS: A total of 200 different plant species (from 71 families) used for traditional malaria treatment were identified in different parts of Ethiopia. Distribution and usage pattern of anti-malarial plants showed substantial variability across different geographic settings. A higher diversity of anti-malarial plants was reported from western and southwestern parts of the country. Analysis of ethno-medicinal recipes indicated that mainly fresh leaves were used for preparation of remedies. Decoction, concoction and eating/chewing were found to be the most frequently employed herbal remedy preparation methods. Notably, anti-malarial herbal remedies were administered by oral route. Information on potential side effects of anti-malarial herbal preparations was patchy. However, some anti-malarial plants were reported to have potentially serious side effects using different local antidotes and some specific contra-indications. CONCLUSION: The study highlighted a rich diversity of indigenous anti-malarial medicinal plants with equally divergent herbal remedy preparation and use pattern in Ethiopia. Baseline information gaps were observed in key geographic settings. Likewise, herbal remedy toxicity risks and countermeasures generally entailed more exhaustive investigation. Experimental research and advanced chemical analysis are also required to validate the therapeutic potential of anti-malarial compounds from promising plant species. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12936-017-1953-2) contains supplementary material, which is available to authorized users. BioMed Central 2017-08-01 /pmc/articles/PMC5540187/ /pubmed/28764723 http://dx.doi.org/10.1186/s12936-017-1953-2 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Alebie, Getachew
Urga, Befikadu
Worku, Amha
Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
title Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
title_full Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
title_fullStr Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
title_full_unstemmed Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
title_short Systematic review on traditional medicinal plants used for the treatment of malaria in Ethiopia: trends and perspectives
title_sort systematic review on traditional medicinal plants used for the treatment of malaria in ethiopia: trends and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540187/
https://www.ncbi.nlm.nih.gov/pubmed/28764723
http://dx.doi.org/10.1186/s12936-017-1953-2
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