Disentangling PTEN-cooperating tumor suppressor gene networks in cancer

We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the...

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Detalles Bibliográficos
Autores principales: de la Rosa, Jorge, Weber, Julia, Rad, Roland, Bradley, Allan, Cadiñanos, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540202/
https://www.ncbi.nlm.nih.gov/pubmed/28868343
http://dx.doi.org/10.1080/23723556.2017.1325550
Descripción
Sumario:We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.

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