Disentangling PTEN-cooperating tumor suppressor gene networks in cancer

We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the...

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Detalles Bibliográficos
Autores principales: de la Rosa, Jorge, Weber, Julia, Rad, Roland, Bradley, Allan, Cadiñanos, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540202/
https://www.ncbi.nlm.nih.gov/pubmed/28868343
http://dx.doi.org/10.1080/23723556.2017.1325550
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author de la Rosa, Jorge
Weber, Julia
Rad, Roland
Bradley, Allan
Cadiñanos, Juan
author_facet de la Rosa, Jorge
Weber, Julia
Rad, Roland
Bradley, Allan
Cadiñanos, Juan
author_sort de la Rosa, Jorge
collection PubMed
description We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.
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spelling pubmed-55402022018-05-04 Disentangling PTEN-cooperating tumor suppressor gene networks in cancer de la Rosa, Jorge Weber, Julia Rad, Roland Bradley, Allan Cadiñanos, Juan Mol Cell Oncol Author's View We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer. Taylor & Francis 2017-05-04 /pmc/articles/PMC5540202/ /pubmed/28868343 http://dx.doi.org/10.1080/23723556.2017.1325550 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
de la Rosa, Jorge
Weber, Julia
Rad, Roland
Bradley, Allan
Cadiñanos, Juan
Disentangling PTEN-cooperating tumor suppressor gene networks in cancer
title Disentangling PTEN-cooperating tumor suppressor gene networks in cancer
title_full Disentangling PTEN-cooperating tumor suppressor gene networks in cancer
title_fullStr Disentangling PTEN-cooperating tumor suppressor gene networks in cancer
title_full_unstemmed Disentangling PTEN-cooperating tumor suppressor gene networks in cancer
title_short Disentangling PTEN-cooperating tumor suppressor gene networks in cancer
title_sort disentangling pten-cooperating tumor suppressor gene networks in cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540202/
https://www.ncbi.nlm.nih.gov/pubmed/28868343
http://dx.doi.org/10.1080/23723556.2017.1325550
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