Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer

Androgen receptor-mediated cell signaling involves complex molecular pathways that are interconnected with DNA damage response, including replication stress-driven DNA repair. Understanding the relationships between androgen receptor signaling and DNA damage response at the molecular level will like...

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Detalles Bibliográficos
Autores principales: Thompson, Timothy C., Li, Likun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540204/
https://www.ncbi.nlm.nih.gov/pubmed/28819638
http://dx.doi.org/10.1080/23723556.2017.1321167
Descripción
Sumario:Androgen receptor-mediated cell signaling involves complex molecular pathways that are interconnected with DNA damage response, including replication stress-driven DNA repair. Understanding the relationships between androgen receptor signaling and DNA damage response at the molecular level will likely lead to novel and effective combination therapy for advanced prostate cancer.

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