Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer

Androgen receptor-mediated cell signaling involves complex molecular pathways that are interconnected with DNA damage response, including replication stress-driven DNA repair. Understanding the relationships between androgen receptor signaling and DNA damage response at the molecular level will like...

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Detalles Bibliográficos
Autores principales: Thompson, Timothy C., Li, Likun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540204/
https://www.ncbi.nlm.nih.gov/pubmed/28819638
http://dx.doi.org/10.1080/23723556.2017.1321167
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author Thompson, Timothy C.
Li, Likun
author_facet Thompson, Timothy C.
Li, Likun
author_sort Thompson, Timothy C.
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description Androgen receptor-mediated cell signaling involves complex molecular pathways that are interconnected with DNA damage response, including replication stress-driven DNA repair. Understanding the relationships between androgen receptor signaling and DNA damage response at the molecular level will likely lead to novel and effective combination therapy for advanced prostate cancer.
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spelling pubmed-55402042018-05-03 Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer Thompson, Timothy C. Li, Likun Mol Cell Oncol Author's View Androgen receptor-mediated cell signaling involves complex molecular pathways that are interconnected with DNA damage response, including replication stress-driven DNA repair. Understanding the relationships between androgen receptor signaling and DNA damage response at the molecular level will likely lead to novel and effective combination therapy for advanced prostate cancer. Taylor & Francis 2017-05-03 /pmc/articles/PMC5540204/ /pubmed/28819638 http://dx.doi.org/10.1080/23723556.2017.1321167 Text en Published with license by Taylor & Francis Group, LLC. © Timothy C. Thompson and Likun Li http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Thompson, Timothy C.
Li, Likun
Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer
title Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer
title_full Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer
title_fullStr Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer
title_full_unstemmed Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer
title_short Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer
title_sort connecting androgen receptor signaling and the dna damage response: development of new therapies for advanced prostate cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540204/
https://www.ncbi.nlm.nih.gov/pubmed/28819638
http://dx.doi.org/10.1080/23723556.2017.1321167
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