STAT5 antagonism of B cell enhancer networks drives leukemia and poor patient survival

The transcription factor STAT5 plays a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we demonstrate that STAT5 activation cooperates with defects in the pre-BCR signaling components encoded by Blnk, Btk, Prkcb, Nfkb1, and Ikzf1 to initi...

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Detalles Bibliográficos
Autores principales: Katerndahl, Casey D.S., Heltemes-Harris, Lynn M., Willette, Mark J.L., Henzler, Christine M., Frietze, Seth, Yang, Rendong, Schjerven, Hilde, Silverstein, Kevin A.T., Ramsey, Laura B., Hubbard, Gregory, Wells, Andrew D., Kuiper, Roland P., Scheijen, Blanca, van Leeuwen, Frank N., Müschen, Markus, Kornblau, Steven M., Farrar, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540372/
https://www.ncbi.nlm.nih.gov/pubmed/28369050
http://dx.doi.org/10.1038/ni.3716

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