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The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer

BACKGROUND: Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1.5 and its ‘neonatal’ splice variant, nNav1.5. Several factors have been associa...

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Detalles Bibliográficos
Autores principales:	Kamarulzaman, Nur Sabrina, Dewadas, Hemaniswarri Dewi, Leow, Chiuan Yee, Yaacob, Nik Soriani, Mokhtar, Noor Fatmawati
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540501/ https://www.ncbi.nlm.nih.gov/pubmed/28785170 http://dx.doi.org/10.1186/s12935-017-0442-6

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