L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin

BACKGROUND: Autotaxin (ATX, NPP-2), originally purified as a potent tumor cell motility factor, is now known to be the long-sought plasma lysophospholipase D (LPLD). The integrity of the enzymatic active site, including three crucial histidine moieties, is required for motility stimulation, as well...

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Detalles Bibliográficos
Autores principales: Clair, Timothy, Koh, Eunjin, Ptaszynska, Malgorzata, Bandle, Russell W, Liotta, Lance A, Schiffmann, Elliott, Stracke, Mary L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554093/
https://www.ncbi.nlm.nih.gov/pubmed/15737239
http://dx.doi.org/10.1186/1476-511X-4-5

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