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Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
Previous work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend these findi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540932/ https://www.ncbi.nlm.nih.gov/pubmed/28769095 http://dx.doi.org/10.1038/s41598-017-07577-y |
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author | Bäckman, Lars Waris, Otto Johansson, Jarkko Andersson, Micael Rinne, Juha O. Alakurtti, Kati Soveri, Anna Laine, Matti Nyberg, Lars |
author_facet | Bäckman, Lars Waris, Otto Johansson, Jarkko Andersson, Micael Rinne, Juha O. Alakurtti, Kati Soveri, Anna Laine, Matti Nyberg, Lars |
author_sort | Bäckman, Lars |
collection | PubMed |
description | Previous work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend these findings by also examining neurochemical correlates of transfer. Four positron emission tomography (PET) scans using the radioligand raclopride were performed. Two of these assessed DAD2 binding (letter memory; n-back) before 5 weeks of updating training, and the same two scans were performed post training. Key findings were (a) pronounced training-related behavioral gains in the letter-memory criterion task, (b) altered striatal DAD2 binding potential after training during letter-memory performance, suggesting training-induced increases in DA release, and (c) increased striatal DA activity also during the n-back transfer task after the intervention, but no concomitant behavioral transfer. The fact that the training-related DA alterations during the transfer task were not accompanied by behavioral transfer suggests that increased DA release may be a necessary, but not sufficient, condition for behavioral transfer to occur. |
format | Online Article Text |
id | pubmed-5540932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55409322017-08-07 Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer Bäckman, Lars Waris, Otto Johansson, Jarkko Andersson, Micael Rinne, Juha O. Alakurtti, Kati Soveri, Anna Laine, Matti Nyberg, Lars Sci Rep Article Previous work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend these findings by also examining neurochemical correlates of transfer. Four positron emission tomography (PET) scans using the radioligand raclopride were performed. Two of these assessed DAD2 binding (letter memory; n-back) before 5 weeks of updating training, and the same two scans were performed post training. Key findings were (a) pronounced training-related behavioral gains in the letter-memory criterion task, (b) altered striatal DAD2 binding potential after training during letter-memory performance, suggesting training-induced increases in DA release, and (c) increased striatal DA activity also during the n-back transfer task after the intervention, but no concomitant behavioral transfer. The fact that the training-related DA alterations during the transfer task were not accompanied by behavioral transfer suggests that increased DA release may be a necessary, but not sufficient, condition for behavioral transfer to occur. Nature Publishing Group UK 2017-08-02 /pmc/articles/PMC5540932/ /pubmed/28769095 http://dx.doi.org/10.1038/s41598-017-07577-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bäckman, Lars Waris, Otto Johansson, Jarkko Andersson, Micael Rinne, Juha O. Alakurtti, Kati Soveri, Anna Laine, Matti Nyberg, Lars Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer |
title | Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer |
title_full | Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer |
title_fullStr | Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer |
title_full_unstemmed | Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer |
title_short | Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer |
title_sort | increased dopamine release after working-memory updating training: neurochemical correlates of transfer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540932/ https://www.ncbi.nlm.nih.gov/pubmed/28769095 http://dx.doi.org/10.1038/s41598-017-07577-y |
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