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The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network

Val66Met, a naturally occurring polymorphism in the human brain-derived neurotrophic factor (BDNF) gene resulting in a valine (Val) to methionine (Met) substitution at codon 66, plays an important role in neuroplasticity. While the effect of the BDNF Val66Met polymorphism on local brain structures h...

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Autores principales: Park, Chang-hyun, Kim, Jungyoon, Namgung, Eun, Lee, Do-Wan, Kim, Geon Ha, Kim, Myeongju, Kim, Nayeon, Kim, Tammy D., Kim, Seunghee, Lyoo, In Kyoon, Yoon, Sujung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541016/
https://www.ncbi.nlm.nih.gov/pubmed/28824404
http://dx.doi.org/10.3389/fnhum.2017.00400
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author Park, Chang-hyun
Kim, Jungyoon
Namgung, Eun
Lee, Do-Wan
Kim, Geon Ha
Kim, Myeongju
Kim, Nayeon
Kim, Tammy D.
Kim, Seunghee
Lyoo, In Kyoon
Yoon, Sujung
author_facet Park, Chang-hyun
Kim, Jungyoon
Namgung, Eun
Lee, Do-Wan
Kim, Geon Ha
Kim, Myeongju
Kim, Nayeon
Kim, Tammy D.
Kim, Seunghee
Lyoo, In Kyoon
Yoon, Sujung
author_sort Park, Chang-hyun
collection PubMed
description Val66Met, a naturally occurring polymorphism in the human brain-derived neurotrophic factor (BDNF) gene resulting in a valine (Val) to methionine (Met) substitution at codon 66, plays an important role in neuroplasticity. While the effect of the BDNF Val66Met polymorphism on local brain structures has previously been examined, its impact on the configuration of the graph-based white matter structural networks is yet to be investigated. In the current study, we assessed the effect of the BDNF polymorphism on the network properties and robustness of the graph-based white matter structural networks. Graph theory was employed to investigate the structural connectivity derived from white matter tractography in two groups, Val homozygotes (n = 18) and Met-allele carriers (n = 55). Although there were no differences in the global network measures including global efficiency, local efficiency, and modularity between the two genotype groups, we found the effect of the BDNF Val66Met polymorphism on the robustness properties of the white matter structural networks. Specifically, the white matter structural networks of the Met-allele carrier group showed higher vulnerability to targeted removal of central nodes as compared with those of the Val homozygote group. These findings suggest that the central role of the BDNF Val66Met polymorphism in regards to neuroplasticity may be associated with inherent differences in the robustness of the white matter structural network according to the genetic variants. Furthermore, greater susceptibility to brain disorders in Met-allele carriers may be understood as being due to their limited stability in white matter structural connectivity.
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spelling pubmed-55410162017-08-18 The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network Park, Chang-hyun Kim, Jungyoon Namgung, Eun Lee, Do-Wan Kim, Geon Ha Kim, Myeongju Kim, Nayeon Kim, Tammy D. Kim, Seunghee Lyoo, In Kyoon Yoon, Sujung Front Hum Neurosci Neuroscience Val66Met, a naturally occurring polymorphism in the human brain-derived neurotrophic factor (BDNF) gene resulting in a valine (Val) to methionine (Met) substitution at codon 66, plays an important role in neuroplasticity. While the effect of the BDNF Val66Met polymorphism on local brain structures has previously been examined, its impact on the configuration of the graph-based white matter structural networks is yet to be investigated. In the current study, we assessed the effect of the BDNF polymorphism on the network properties and robustness of the graph-based white matter structural networks. Graph theory was employed to investigate the structural connectivity derived from white matter tractography in two groups, Val homozygotes (n = 18) and Met-allele carriers (n = 55). Although there were no differences in the global network measures including global efficiency, local efficiency, and modularity between the two genotype groups, we found the effect of the BDNF Val66Met polymorphism on the robustness properties of the white matter structural networks. Specifically, the white matter structural networks of the Met-allele carrier group showed higher vulnerability to targeted removal of central nodes as compared with those of the Val homozygote group. These findings suggest that the central role of the BDNF Val66Met polymorphism in regards to neuroplasticity may be associated with inherent differences in the robustness of the white matter structural network according to the genetic variants. Furthermore, greater susceptibility to brain disorders in Met-allele carriers may be understood as being due to their limited stability in white matter structural connectivity. Frontiers Media S.A. 2017-08-03 /pmc/articles/PMC5541016/ /pubmed/28824404 http://dx.doi.org/10.3389/fnhum.2017.00400 Text en Copyright © 2017 Park, Kim, Namgung, Lee, Kim, Kim, Kim, Kim, Kim, Lyoo and Yoon. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Park, Chang-hyun
Kim, Jungyoon
Namgung, Eun
Lee, Do-Wan
Kim, Geon Ha
Kim, Myeongju
Kim, Nayeon
Kim, Tammy D.
Kim, Seunghee
Lyoo, In Kyoon
Yoon, Sujung
The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network
title The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network
title_full The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network
title_fullStr The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network
title_full_unstemmed The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network
title_short The BDNF Val66Met Polymorphism Affects the Vulnerability of the Brain Structural Network
title_sort bdnf val66met polymorphism affects the vulnerability of the brain structural network
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541016/
https://www.ncbi.nlm.nih.gov/pubmed/28824404
http://dx.doi.org/10.3389/fnhum.2017.00400
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