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Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives
Zika virus (ZIKV) remained largely quiescent for nearly six decades after its first appearance in 1947. ZIKV reappeared after 2007, resulting in a declaration of an international “public health emergency” in 2016 by the World Health Organization (WHO). Until this time, ZIKV was considered to induce...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541032/ https://www.ncbi.nlm.nih.gov/pubmed/28824594 http://dx.doi.org/10.3389/fmicb.2017.01469 |
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author | Munjal, Ashok Khandia, Rekha Dhama, Kuldeep Sachan, Swati Karthik, Kumaragurubaran Tiwari, Ruchi Malik, Yashpal S. Kumar, Deepak Singh, Raj K. Iqbal, Hafiz M. N. Joshi, Sunil K. |
author_facet | Munjal, Ashok Khandia, Rekha Dhama, Kuldeep Sachan, Swati Karthik, Kumaragurubaran Tiwari, Ruchi Malik, Yashpal S. Kumar, Deepak Singh, Raj K. Iqbal, Hafiz M. N. Joshi, Sunil K. |
author_sort | Munjal, Ashok |
collection | PubMed |
description | Zika virus (ZIKV) remained largely quiescent for nearly six decades after its first appearance in 1947. ZIKV reappeared after 2007, resulting in a declaration of an international “public health emergency” in 2016 by the World Health Organization (WHO). Until this time, ZIKV was considered to induce only mild illness, but it has now been established as the cause of severe clinical manifestations, including fetal anomalies, neurological problems, and autoimmune disorders. Infection during pregnancy can cause congenital brain abnormalities, including microcephaly and neurological degeneration, and in other cases, Guillain-Barré syndrome, making infections with ZIKV a substantial public health concern. Genomic and molecular investigations are underway to investigate ZIKV pathology and its recent enhanced pathogenicity, as well as to design safe and potent vaccines, drugs, and therapeutics. This review describes progress in the design and development of various anti-ZIKV therapeutics, including drugs targeting virus entry into cells and the helicase protein, nucleosides, inhibitors of NS3 protein, small molecules, methyltransferase inhibitors, interferons, repurposed drugs, drugs designed with the aid of computers, neutralizing antibodies, convalescent serum, antibodies that limit antibody-dependent enhancement, and herbal medicines. Additionally, covalent inhibitors of viral protein expression and anti-Toll-like receptor molecules are discussed. To counter ZIKV-associated disease, we need to make rapid progress in developing novel therapies that work effectually to inhibit ZIKV. |
format | Online Article Text |
id | pubmed-5541032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55410322017-08-18 Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives Munjal, Ashok Khandia, Rekha Dhama, Kuldeep Sachan, Swati Karthik, Kumaragurubaran Tiwari, Ruchi Malik, Yashpal S. Kumar, Deepak Singh, Raj K. Iqbal, Hafiz M. N. Joshi, Sunil K. Front Microbiol Microbiology Zika virus (ZIKV) remained largely quiescent for nearly six decades after its first appearance in 1947. ZIKV reappeared after 2007, resulting in a declaration of an international “public health emergency” in 2016 by the World Health Organization (WHO). Until this time, ZIKV was considered to induce only mild illness, but it has now been established as the cause of severe clinical manifestations, including fetal anomalies, neurological problems, and autoimmune disorders. Infection during pregnancy can cause congenital brain abnormalities, including microcephaly and neurological degeneration, and in other cases, Guillain-Barré syndrome, making infections with ZIKV a substantial public health concern. Genomic and molecular investigations are underway to investigate ZIKV pathology and its recent enhanced pathogenicity, as well as to design safe and potent vaccines, drugs, and therapeutics. This review describes progress in the design and development of various anti-ZIKV therapeutics, including drugs targeting virus entry into cells and the helicase protein, nucleosides, inhibitors of NS3 protein, small molecules, methyltransferase inhibitors, interferons, repurposed drugs, drugs designed with the aid of computers, neutralizing antibodies, convalescent serum, antibodies that limit antibody-dependent enhancement, and herbal medicines. Additionally, covalent inhibitors of viral protein expression and anti-Toll-like receptor molecules are discussed. To counter ZIKV-associated disease, we need to make rapid progress in developing novel therapies that work effectually to inhibit ZIKV. Frontiers Media S.A. 2017-08-03 /pmc/articles/PMC5541032/ /pubmed/28824594 http://dx.doi.org/10.3389/fmicb.2017.01469 Text en Copyright © 2017 Munjal, Khandia, Dhama, Sachan, Karthik, Tiwari, Malik, Kumar, Singh, Iqbal and Joshi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Munjal, Ashok Khandia, Rekha Dhama, Kuldeep Sachan, Swati Karthik, Kumaragurubaran Tiwari, Ruchi Malik, Yashpal S. Kumar, Deepak Singh, Raj K. Iqbal, Hafiz M. N. Joshi, Sunil K. Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives |
title | Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives |
title_full | Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives |
title_fullStr | Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives |
title_full_unstemmed | Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives |
title_short | Advances in Developing Therapies to Combat Zika Virus: Current Knowledge and Future Perspectives |
title_sort | advances in developing therapies to combat zika virus: current knowledge and future perspectives |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541032/ https://www.ncbi.nlm.nih.gov/pubmed/28824594 http://dx.doi.org/10.3389/fmicb.2017.01469 |
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