Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency

Autosomal dominant polycystic kidney disease (ADPKD) is a common kidney disease caused by mutations in PKD1 or PKD2. Metformin reduces cyst growth in mouse models of PKD1. However, metformin has not been studied in animal models of PKD2, and the cellular mechanism underlying its effectiveness is not...

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Detalles Bibliográficos
Autores principales: Chang, Ming-Yang, Ma, Tsu-Lin, Hung, Cheng-Chieh, Tian, Ya-Chung, Chen, Yung-Chang, Yang, Chih-Wei, Cheng, Yi-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541071/
https://www.ncbi.nlm.nih.gov/pubmed/28769124
http://dx.doi.org/10.1038/s41598-017-07300-x

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