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High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder
We carried out whole-exome ultra-high throughput sequencing in brain samples of suicide victims who had suffered from major depressive disorder and control subjects who had died from other causes. This study aimed to reveal the selective accumulation of rare variants in the coding and the UTR sequen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541090/ https://www.ncbi.nlm.nih.gov/pubmed/28769055 http://dx.doi.org/10.1038/s41598-017-06522-3 |
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author | Tombácz, Dóra Maróti, Zoltán Kalmár, Tibor Csabai, Zsolt Balázs, Zsolt Takahashi, Shinichi Palkovits, Miklós Snyder, Michael Boldogkői, Zsolt |
author_facet | Tombácz, Dóra Maróti, Zoltán Kalmár, Tibor Csabai, Zsolt Balázs, Zsolt Takahashi, Shinichi Palkovits, Miklós Snyder, Michael Boldogkői, Zsolt |
author_sort | Tombácz, Dóra |
collection | PubMed |
description | We carried out whole-exome ultra-high throughput sequencing in brain samples of suicide victims who had suffered from major depressive disorder and control subjects who had died from other causes. This study aimed to reveal the selective accumulation of rare variants in the coding and the UTR sequences within the genes of suicide victims. We also analysed the potential effect of STR and CNV variations, as well as the infection of the brain with neurovirulent viruses in this behavioural disorder. As a result, we have identified several candidate genes, among others three calcium channel genes that may potentially contribute to completed suicide. We also explored the potential implication of the TGF-β signalling pathway in the pathogenesis of suicidal behaviour. To our best knowledge, this is the first study that uses whole-exome sequencing for the investigation of suicide. |
format | Online Article Text |
id | pubmed-5541090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55410902017-08-07 High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder Tombácz, Dóra Maróti, Zoltán Kalmár, Tibor Csabai, Zsolt Balázs, Zsolt Takahashi, Shinichi Palkovits, Miklós Snyder, Michael Boldogkői, Zsolt Sci Rep Article We carried out whole-exome ultra-high throughput sequencing in brain samples of suicide victims who had suffered from major depressive disorder and control subjects who had died from other causes. This study aimed to reveal the selective accumulation of rare variants in the coding and the UTR sequences within the genes of suicide victims. We also analysed the potential effect of STR and CNV variations, as well as the infection of the brain with neurovirulent viruses in this behavioural disorder. As a result, we have identified several candidate genes, among others three calcium channel genes that may potentially contribute to completed suicide. We also explored the potential implication of the TGF-β signalling pathway in the pathogenesis of suicidal behaviour. To our best knowledge, this is the first study that uses whole-exome sequencing for the investigation of suicide. Nature Publishing Group UK 2017-08-02 /pmc/articles/PMC5541090/ /pubmed/28769055 http://dx.doi.org/10.1038/s41598-017-06522-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tombácz, Dóra Maróti, Zoltán Kalmár, Tibor Csabai, Zsolt Balázs, Zsolt Takahashi, Shinichi Palkovits, Miklós Snyder, Michael Boldogkői, Zsolt High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder |
title | High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder |
title_full | High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder |
title_fullStr | High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder |
title_full_unstemmed | High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder |
title_short | High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder |
title_sort | high-coverage whole-exome sequencing identifies candidate genes for suicide in victims with major depressive disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541090/ https://www.ncbi.nlm.nih.gov/pubmed/28769055 http://dx.doi.org/10.1038/s41598-017-06522-3 |
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