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Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study

BACKGROUND: Fat mass, which is a major component of body weight, is directly related to bone mineral density and reduced fracture risk. It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fract...

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Autores principales: Nguyen, Nguyen D, Pongchaiyakul, Chatlert, Center, Jacqueline R, Eisman, John A, Nguyen, Tuan V
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554111/
https://www.ncbi.nlm.nih.gov/pubmed/15727686
http://dx.doi.org/10.1186/1471-2474-6-11
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author Nguyen, Nguyen D
Pongchaiyakul, Chatlert
Center, Jacqueline R
Eisman, John A
Nguyen, Tuan V
author_facet Nguyen, Nguyen D
Pongchaiyakul, Chatlert
Center, Jacqueline R
Eisman, John A
Nguyen, Tuan V
author_sort Nguyen, Nguyen D
collection PubMed
description BACKGROUND: Fat mass, which is a major component of body weight, is directly related to bone mineral density and reduced fracture risk. It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years. METHODS: This was a nested case-control study with one fracture case being matched with two controls of the same age. In women 63 cases were matched with 126 controls, and in men 26 cases were matched with 52 controls. Hip fracture was confirmed by X-ray and personal interview. Other measurements included weight, height, body mass index (BMI), abdominal fat, and femoral neck bone density (FNBMD). Conditional logistic regression model was used to analyse data. RESULTS: The odds ratio of hip fracture risk associated with each 10% lower abdominal fat was 1.5 (95% CI, 1.1 to 2.1) in women and 1.2 (95% CI, 0.7 to 2.0) in men. However after adjusting for FNBMD or body weight, the abdominal fat-fracture association was no longer statistically significant. Similarly, body weight and BMI was each significantly associated with hip fracture risk (in women), but after taking with account the effect of FNBMD, the association become statistically non-significant. CONCLUSION: Lower abdominal fat was associated with an increased risk of hip fracture in elderly women, but the association was not independent of FNBMD or weight. The contribution of abdominal fat to hip fracture risk is likely to be modest.
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spelling pubmed-5541112005-03-13 Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study Nguyen, Nguyen D Pongchaiyakul, Chatlert Center, Jacqueline R Eisman, John A Nguyen, Tuan V BMC Musculoskelet Disord Research Article BACKGROUND: Fat mass, which is a major component of body weight, is directly related to bone mineral density and reduced fracture risk. It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years. METHODS: This was a nested case-control study with one fracture case being matched with two controls of the same age. In women 63 cases were matched with 126 controls, and in men 26 cases were matched with 52 controls. Hip fracture was confirmed by X-ray and personal interview. Other measurements included weight, height, body mass index (BMI), abdominal fat, and femoral neck bone density (FNBMD). Conditional logistic regression model was used to analyse data. RESULTS: The odds ratio of hip fracture risk associated with each 10% lower abdominal fat was 1.5 (95% CI, 1.1 to 2.1) in women and 1.2 (95% CI, 0.7 to 2.0) in men. However after adjusting for FNBMD or body weight, the abdominal fat-fracture association was no longer statistically significant. Similarly, body weight and BMI was each significantly associated with hip fracture risk (in women), but after taking with account the effect of FNBMD, the association become statistically non-significant. CONCLUSION: Lower abdominal fat was associated with an increased risk of hip fracture in elderly women, but the association was not independent of FNBMD or weight. The contribution of abdominal fat to hip fracture risk is likely to be modest. BioMed Central 2005-02-23 /pmc/articles/PMC554111/ /pubmed/15727686 http://dx.doi.org/10.1186/1471-2474-6-11 Text en Copyright © 2005 Nguyen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nguyen, Nguyen D
Pongchaiyakul, Chatlert
Center, Jacqueline R
Eisman, John A
Nguyen, Tuan V
Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
title Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
title_full Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
title_fullStr Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
title_full_unstemmed Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
title_short Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
title_sort abdominal fat and hip fracture risk in the elderly: the dubbo osteoporosis epidemiology study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554111/
https://www.ncbi.nlm.nih.gov/pubmed/15727686
http://dx.doi.org/10.1186/1471-2474-6-11
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