Cargando…

Long-term use of bisphosphonates in osteoporosis

OBJECTIVES: To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms. METHODS: This is a single center obse...

Descripción completa

Detalles Bibliográficos
Autores principales: Alwahhabi, Basmah K., Alsuwaine, Basil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541183/
https://www.ncbi.nlm.nih.gov/pubmed/28578439
http://dx.doi.org/10.15537/smj.2017.6.19793
_version_ 1783254768971415552
author Alwahhabi, Basmah K.
Alsuwaine, Basil A.
author_facet Alwahhabi, Basmah K.
Alsuwaine, Basil A.
author_sort Alwahhabi, Basmah K.
collection PubMed
description OBJECTIVES: To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms. METHODS: This is a single center observational retrospective cohort study conducted from January 2009 to May 2016 in a tertiary center. We describe cause of referral, X-rays findings, management, and response to treatment. RESULTS: Thirty-four patients, aged 46-89 years, were collected. Reason for referral included review of therapy (11 patients), recent low trauma fracture (21 patients), or chronic severe thigh pain (2 patients) of unknown etiology. All patients with fracture or thigh pain (23/34 patients) were treated with teriparatide 20 mcg daily. Sixteen of them (16/23) completed teriparatide course (18-24 months), 11 patients had complete healing of fracture at the end of the course, and 5 remained with nonunion of fracture, the remaining 5 patients were lost to follow up. CONCLUSION: Prolonged use of bisphosphonates can lead to atypical femoral fracture that may involve sites other than femoral shaft or rarely chronic thigh pain without fracture. Teriparatide may facilitates fracture healing and improve thigh pain.
format Online
Article
Text
id pubmed-5541183
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Saudi Medical Journal
record_format MEDLINE/PubMed
spelling pubmed-55411832017-08-10 Long-term use of bisphosphonates in osteoporosis Alwahhabi, Basmah K. Alsuwaine, Basil A. Saudi Med J Original Article OBJECTIVES: To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms. METHODS: This is a single center observational retrospective cohort study conducted from January 2009 to May 2016 in a tertiary center. We describe cause of referral, X-rays findings, management, and response to treatment. RESULTS: Thirty-four patients, aged 46-89 years, were collected. Reason for referral included review of therapy (11 patients), recent low trauma fracture (21 patients), or chronic severe thigh pain (2 patients) of unknown etiology. All patients with fracture or thigh pain (23/34 patients) were treated with teriparatide 20 mcg daily. Sixteen of them (16/23) completed teriparatide course (18-24 months), 11 patients had complete healing of fracture at the end of the course, and 5 remained with nonunion of fracture, the remaining 5 patients were lost to follow up. CONCLUSION: Prolonged use of bisphosphonates can lead to atypical femoral fracture that may involve sites other than femoral shaft or rarely chronic thigh pain without fracture. Teriparatide may facilitates fracture healing and improve thigh pain. Saudi Medical Journal 2017-06 /pmc/articles/PMC5541183/ /pubmed/28578439 http://dx.doi.org/10.15537/smj.2017.6.19793 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alwahhabi, Basmah K.
Alsuwaine, Basil A.
Long-term use of bisphosphonates in osteoporosis
title Long-term use of bisphosphonates in osteoporosis
title_full Long-term use of bisphosphonates in osteoporosis
title_fullStr Long-term use of bisphosphonates in osteoporosis
title_full_unstemmed Long-term use of bisphosphonates in osteoporosis
title_short Long-term use of bisphosphonates in osteoporosis
title_sort long-term use of bisphosphonates in osteoporosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541183/
https://www.ncbi.nlm.nih.gov/pubmed/28578439
http://dx.doi.org/10.15537/smj.2017.6.19793
work_keys_str_mv AT alwahhabibasmahk longtermuseofbisphosphonatesinosteoporosis
AT alsuwainebasila longtermuseofbisphosphonatesinosteoporosis