Cargando…
Long-term use of bisphosphonates in osteoporosis
OBJECTIVES: To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms. METHODS: This is a single center obse...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Saudi Medical Journal
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541183/ https://www.ncbi.nlm.nih.gov/pubmed/28578439 http://dx.doi.org/10.15537/smj.2017.6.19793 |
_version_ | 1783254768971415552 |
---|---|
author | Alwahhabi, Basmah K. Alsuwaine, Basil A. |
author_facet | Alwahhabi, Basmah K. Alsuwaine, Basil A. |
author_sort | Alwahhabi, Basmah K. |
collection | PubMed |
description | OBJECTIVES: To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms. METHODS: This is a single center observational retrospective cohort study conducted from January 2009 to May 2016 in a tertiary center. We describe cause of referral, X-rays findings, management, and response to treatment. RESULTS: Thirty-four patients, aged 46-89 years, were collected. Reason for referral included review of therapy (11 patients), recent low trauma fracture (21 patients), or chronic severe thigh pain (2 patients) of unknown etiology. All patients with fracture or thigh pain (23/34 patients) were treated with teriparatide 20 mcg daily. Sixteen of them (16/23) completed teriparatide course (18-24 months), 11 patients had complete healing of fracture at the end of the course, and 5 remained with nonunion of fracture, the remaining 5 patients were lost to follow up. CONCLUSION: Prolonged use of bisphosphonates can lead to atypical femoral fracture that may involve sites other than femoral shaft or rarely chronic thigh pain without fracture. Teriparatide may facilitates fracture healing and improve thigh pain. |
format | Online Article Text |
id | pubmed-5541183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Saudi Medical Journal |
record_format | MEDLINE/PubMed |
spelling | pubmed-55411832017-08-10 Long-term use of bisphosphonates in osteoporosis Alwahhabi, Basmah K. Alsuwaine, Basil A. Saudi Med J Original Article OBJECTIVES: To report and describe the management and response to treatment of patients referred to the osteoporosis clinic after prolonged use of bisphosphonate BPs) (4 years and more) with and without new fracture (any site) or any other new skeletal symptoms. METHODS: This is a single center observational retrospective cohort study conducted from January 2009 to May 2016 in a tertiary center. We describe cause of referral, X-rays findings, management, and response to treatment. RESULTS: Thirty-four patients, aged 46-89 years, were collected. Reason for referral included review of therapy (11 patients), recent low trauma fracture (21 patients), or chronic severe thigh pain (2 patients) of unknown etiology. All patients with fracture or thigh pain (23/34 patients) were treated with teriparatide 20 mcg daily. Sixteen of them (16/23) completed teriparatide course (18-24 months), 11 patients had complete healing of fracture at the end of the course, and 5 remained with nonunion of fracture, the remaining 5 patients were lost to follow up. CONCLUSION: Prolonged use of bisphosphonates can lead to atypical femoral fracture that may involve sites other than femoral shaft or rarely chronic thigh pain without fracture. Teriparatide may facilitates fracture healing and improve thigh pain. Saudi Medical Journal 2017-06 /pmc/articles/PMC5541183/ /pubmed/28578439 http://dx.doi.org/10.15537/smj.2017.6.19793 Text en Copyright: © Saudi Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Alwahhabi, Basmah K. Alsuwaine, Basil A. Long-term use of bisphosphonates in osteoporosis |
title | Long-term use of bisphosphonates in osteoporosis |
title_full | Long-term use of bisphosphonates in osteoporosis |
title_fullStr | Long-term use of bisphosphonates in osteoporosis |
title_full_unstemmed | Long-term use of bisphosphonates in osteoporosis |
title_short | Long-term use of bisphosphonates in osteoporosis |
title_sort | long-term use of bisphosphonates in osteoporosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541183/ https://www.ncbi.nlm.nih.gov/pubmed/28578439 http://dx.doi.org/10.15537/smj.2017.6.19793 |
work_keys_str_mv | AT alwahhabibasmahk longtermuseofbisphosphonatesinosteoporosis AT alsuwainebasila longtermuseofbisphosphonatesinosteoporosis |