CD133(+) brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence

Medulloblastoma (MB), the most common malignant paediatric brain tumor, is currently treated using a combination of surgery, craniospinal radiotherapy and chemotherapy. Owing to MB stem cells (MBSCs), a subset of MB patients remains untreatable despite standard therapy. CD133 is used to identify MBS...

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Detalles Bibliográficos
Autores principales: Garg, N, Bakhshinyan, D, Venugopal, C, Mahendram, S, Rosa, D A, Vijayakumar, T, Manoranjan, B, Hallett, R, McFarlane, N, Delaney, K H, Kwiecien, J M, Arpin, C C, Lai, P-S, Gómez-Biagi, R F, Ali, A M, de Araujo, E D, Ajani, O A, Hassell, J A, Gunning, P T, Singh, S K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541269/
https://www.ncbi.nlm.nih.gov/pubmed/27775079
http://dx.doi.org/10.1038/onc.2016.235

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