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Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses
Eupatorium fortunei (EF) has long been used as herbal medicine in Korea, China, and Asian countries to treat a variety of diseases. Recent studies have reported that EF has anti-metastatic, anti-angiogenic, anti-bacterial, and anti-oxidant activities, as well as activities against malignant metastat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541272/ https://www.ncbi.nlm.nih.gov/pubmed/28824435 http://dx.doi.org/10.3389/fphar.2017.00511 |
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author | Choi, Jang-Gi Lee, Heeeun Hwang, Youn-Hwan Lee, Jong-Soo Cho, Won-Kyung Ma, Jin Yeul |
author_facet | Choi, Jang-Gi Lee, Heeeun Hwang, Youn-Hwan Lee, Jong-Soo Cho, Won-Kyung Ma, Jin Yeul |
author_sort | Choi, Jang-Gi |
collection | PubMed |
description | Eupatorium fortunei (EF) has long been used as herbal medicine in Korea, China, and Asian countries to treat a variety of diseases. Recent studies have reported that EF has anti-metastatic, anti-angiogenic, anti-bacterial, and anti-oxidant activities, as well as activities against malignant metastatic human cancers. The effect of EF and its components on viruses has not been reported. In the present study, the antiviral activity and mechanism of action of an aqueous extract of EF (WEF) and its components were evaluated in vitro. We found that pretreatment with WEF markedly reduced viral replication, as evaluated using a green fluorescent protein (GFP)-tagged virus (influenza A virus, Newcastle disease virus, and vesicular stomatitis virus) in murine RAW 264.7 macrophage cells. We demonstrated that WEF induces the production of type I IFN including pro-inflammatory cytokines. Additionally, we identified the active anti-viral components of WEF as quercetin, psoralen, and quercitrin. Thus, WEF and its active components are immunomodulators of the innate immune response in murine macrophages, a finding that is potentially useful to developing prophylactic or therapeutic treatments against a range of viruses. |
format | Online Article Text |
id | pubmed-5541272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55412722017-08-18 Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses Choi, Jang-Gi Lee, Heeeun Hwang, Youn-Hwan Lee, Jong-Soo Cho, Won-Kyung Ma, Jin Yeul Front Pharmacol Pharmacology Eupatorium fortunei (EF) has long been used as herbal medicine in Korea, China, and Asian countries to treat a variety of diseases. Recent studies have reported that EF has anti-metastatic, anti-angiogenic, anti-bacterial, and anti-oxidant activities, as well as activities against malignant metastatic human cancers. The effect of EF and its components on viruses has not been reported. In the present study, the antiviral activity and mechanism of action of an aqueous extract of EF (WEF) and its components were evaluated in vitro. We found that pretreatment with WEF markedly reduced viral replication, as evaluated using a green fluorescent protein (GFP)-tagged virus (influenza A virus, Newcastle disease virus, and vesicular stomatitis virus) in murine RAW 264.7 macrophage cells. We demonstrated that WEF induces the production of type I IFN including pro-inflammatory cytokines. Additionally, we identified the active anti-viral components of WEF as quercetin, psoralen, and quercitrin. Thus, WEF and its active components are immunomodulators of the innate immune response in murine macrophages, a finding that is potentially useful to developing prophylactic or therapeutic treatments against a range of viruses. Frontiers Media S.A. 2017-08-03 /pmc/articles/PMC5541272/ /pubmed/28824435 http://dx.doi.org/10.3389/fphar.2017.00511 Text en Copyright © 2017 Choi, Lee, Hwang, Lee, Cho and Ma. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Choi, Jang-Gi Lee, Heeeun Hwang, Youn-Hwan Lee, Jong-Soo Cho, Won-Kyung Ma, Jin Yeul Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses |
title | Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses |
title_full | Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses |
title_fullStr | Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses |
title_full_unstemmed | Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses |
title_short | Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses |
title_sort | eupatorium fortunei and its components increase antiviral immune responses against rna viruses |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541272/ https://www.ncbi.nlm.nih.gov/pubmed/28824435 http://dx.doi.org/10.3389/fphar.2017.00511 |
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