The Telomeric Complex and Metabolic Disease

The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a c...

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Autores principales: Kirchner, Henriette, Shaheen, Fozia, Kalscheuer, Hannes, Schmid, Sebastian M., Oster, Henrik, Lehnert, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541309/
https://www.ncbi.nlm.nih.gov/pubmed/28686177
http://dx.doi.org/10.3390/genes8070176
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author Kirchner, Henriette
Shaheen, Fozia
Kalscheuer, Hannes
Schmid, Sebastian M.
Oster, Henrik
Lehnert, Hendrik
author_facet Kirchner, Henriette
Shaheen, Fozia
Kalscheuer, Hannes
Schmid, Sebastian M.
Oster, Henrik
Lehnert, Hendrik
author_sort Kirchner, Henriette
collection PubMed
description The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases.
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spelling pubmed-55413092017-08-08 The Telomeric Complex and Metabolic Disease Kirchner, Henriette Shaheen, Fozia Kalscheuer, Hannes Schmid, Sebastian M. Oster, Henrik Lehnert, Hendrik Genes (Basel) Review The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damaging events that ultimately may lead or contribute to telomere shortening and can be associated with metabolic diseases. MDPI 2017-07-07 /pmc/articles/PMC5541309/ /pubmed/28686177 http://dx.doi.org/10.3390/genes8070176 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kirchner, Henriette
Shaheen, Fozia
Kalscheuer, Hannes
Schmid, Sebastian M.
Oster, Henrik
Lehnert, Hendrik
The Telomeric Complex and Metabolic Disease
title The Telomeric Complex and Metabolic Disease
title_full The Telomeric Complex and Metabolic Disease
title_fullStr The Telomeric Complex and Metabolic Disease
title_full_unstemmed The Telomeric Complex and Metabolic Disease
title_short The Telomeric Complex and Metabolic Disease
title_sort telomeric complex and metabolic disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541309/
https://www.ncbi.nlm.nih.gov/pubmed/28686177
http://dx.doi.org/10.3390/genes8070176
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