The effect of blinding on estimates of mortality in randomised clinical trials of intensive care interventions: protocol for a systematic review and meta-analysis

INTRODUCTION: Evidence exists that unblinded randomised clinical trials (RCTs) overestimate intervention effects compared with blinded RCTs. It has been suggested that this is less pronounced for objective (ie, not subject to interpretation) outcome measures, including mortality. This may not apply...

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Detalles Bibliográficos
Autores principales: Anthon, Carl Thomas, Granholm, Anders, Perner, Anders, Laake, Jon Henrik, Møller, Morten Hylander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Open 2017
Materias:
Intensive Care
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541632/
https://www.ncbi.nlm.nih.gov/pubmed/28701412
http://dx.doi.org/10.1136/bmjopen-2017-016187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541632/
https://www.ncbi.nlm.nih.gov/pubmed/28701412
http://dx.doi.org/10.1136/bmjopen-2017-016187

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