Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate intracellular signalling pathways that promote cancer cell survival and tumour growth. Pancreatic cancer is one of the stiffest of all human solid carcinomas and is characterised by a remarkable desmoplastic r...

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Detalles Bibliográficos
Autores principales: Rice, A J, Cortes, E, Lachowski, D, Cheung, B C H, Karim, S A, Morton, J P, del Río Hernández, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541706/
https://www.ncbi.nlm.nih.gov/pubmed/28671675
http://dx.doi.org/10.1038/oncsis.2017.54

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