Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells

MUC1-C overexpression has been associated with the progression of pancreatic tumors by promoting the aggressive and metastatic phenotypes. As MUC1 is a STAT3 target gene, STAT3 plays a major role in regulating MUC1-C expression. In this study, we report an alternative mechanism by which integrin-lin...

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Detalles Bibliográficos
Autores principales: Huang, H-L, Wu, H-Y, Chu, P-C, Lai, I-L, Huang, P-H, Kulp, S K, Pan, S-L, Teng, C-M, Chen, C-S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541713/
https://www.ncbi.nlm.nih.gov/pubmed/28692035
http://dx.doi.org/10.1038/oncsis.2017.61

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