Cargando…

HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC

The purpose of this study was to investigate the HOX gene expression profile in laryngeal squamous cell carcinoma (LSCC) and assess whether some genes are associated with the clinicopathological features and prognosis in LSCC patients. The HOX gene levels were tested by microarray and validated by q...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Chuanhui, Han, Changsong, Wang, Peng, Jin, Yinji, Sun, Yanan, Qu, Lingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541786/
https://www.ncbi.nlm.nih.gov/pubmed/28808656
http://dx.doi.org/10.1155/2017/3680305
_version_ 1783254876885614592
author Sun, Chuanhui
Han, Changsong
Wang, Peng
Jin, Yinji
Sun, Yanan
Qu, Lingmei
author_facet Sun, Chuanhui
Han, Changsong
Wang, Peng
Jin, Yinji
Sun, Yanan
Qu, Lingmei
author_sort Sun, Chuanhui
collection PubMed
description The purpose of this study was to investigate the HOX gene expression profile in laryngeal squamous cell carcinoma (LSCC) and assess whether some genes are associated with the clinicopathological features and prognosis in LSCC patients. The HOX gene levels were tested by microarray and validated by qRT-PCR in paired cancerous and adjacent noncancerous LSCC tissue samples. The microarray testing data of 39 HOX genes revealed 15 HOX genes that were at least 2-fold upregulated and 2 that were downregulated. After qRT-PCR evaluation, the three most upregulated genes (HOXB9, HOXB13, and HOXD13) were selected for tissue microarray (TMA) analysis. The correlations between the HOXB9, HOXB13, and HOXD13 expression levels and both clinicopathological features and prognosis were analyzed. Three HOX gene expression levels were markedly increased in LSCC tissues compared with adjacent noncancerous tissues (P < 0.001). HOXB9 was found to correlate with histological grade (P < 0.01) and prognosis (P < 0.01) in LSCC. In conclusion, this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in LSCC. Moreover, HOXB9 may serve as a novel marker of poor prognosis and a potential therapeutic target in LSCC patients.
format Online
Article
Text
id pubmed-5541786
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-55417862017-08-14 HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC Sun, Chuanhui Han, Changsong Wang, Peng Jin, Yinji Sun, Yanan Qu, Lingmei Biomed Res Int Research Article The purpose of this study was to investigate the HOX gene expression profile in laryngeal squamous cell carcinoma (LSCC) and assess whether some genes are associated with the clinicopathological features and prognosis in LSCC patients. The HOX gene levels were tested by microarray and validated by qRT-PCR in paired cancerous and adjacent noncancerous LSCC tissue samples. The microarray testing data of 39 HOX genes revealed 15 HOX genes that were at least 2-fold upregulated and 2 that were downregulated. After qRT-PCR evaluation, the three most upregulated genes (HOXB9, HOXB13, and HOXD13) were selected for tissue microarray (TMA) analysis. The correlations between the HOXB9, HOXB13, and HOXD13 expression levels and both clinicopathological features and prognosis were analyzed. Three HOX gene expression levels were markedly increased in LSCC tissues compared with adjacent noncancerous tissues (P < 0.001). HOXB9 was found to correlate with histological grade (P < 0.01) and prognosis (P < 0.01) in LSCC. In conclusion, this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in LSCC. Moreover, HOXB9 may serve as a novel marker of poor prognosis and a potential therapeutic target in LSCC patients. Hindawi 2017 2017-07-20 /pmc/articles/PMC5541786/ /pubmed/28808656 http://dx.doi.org/10.1155/2017/3680305 Text en Copyright © 2017 Chuanhui Sun et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Chuanhui
Han, Changsong
Wang, Peng
Jin, Yinji
Sun, Yanan
Qu, Lingmei
HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC
title HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC
title_full HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC
title_fullStr HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC
title_full_unstemmed HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC
title_short HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC
title_sort hoxb9 expression correlates with histological grade and prognosis in lscc
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541786/
https://www.ncbi.nlm.nih.gov/pubmed/28808656
http://dx.doi.org/10.1155/2017/3680305
work_keys_str_mv AT sunchuanhui hoxb9expressioncorrelateswithhistologicalgradeandprognosisinlscc
AT hanchangsong hoxb9expressioncorrelateswithhistologicalgradeandprognosisinlscc
AT wangpeng hoxb9expressioncorrelateswithhistologicalgradeandprognosisinlscc
AT jinyinji hoxb9expressioncorrelateswithhistologicalgradeandprognosisinlscc
AT sunyanan hoxb9expressioncorrelateswithhistologicalgradeandprognosisinlscc
AT qulingmei hoxb9expressioncorrelateswithhistologicalgradeandprognosisinlscc