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Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania

PROBLEM: Factors related to MDRTB mortality in Tanzania have not been adequately explored and reported. OBJECTIVES: To determine demographic, clinical, radiographic, and laboratory factors associated with MDRTB mortality in a Tanzanian TB Referral Hospital. METHODOLOGY: This was a cross-sectional st...

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Autores principales: Mollel, Edson W., Chilongola, Jaffu O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541808/
https://www.ncbi.nlm.nih.gov/pubmed/28808447
http://dx.doi.org/10.1155/2017/9241238
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author Mollel, Edson W.
Chilongola, Jaffu O.
author_facet Mollel, Edson W.
Chilongola, Jaffu O.
author_sort Mollel, Edson W.
collection PubMed
description PROBLEM: Factors related to MDRTB mortality in Tanzania have not been adequately explored and reported. OBJECTIVES: To determine demographic, clinical, radiographic, and laboratory factors associated with MDRTB mortality in a Tanzanian TB Referral Hospital. METHODOLOGY: This was a cross-sectional study with 193 participants. Demographic, clinical, laboratory, and radiological data were collected, and their associations with mortality among MDRTB patients were determined. RESULTS AND CONCLUSIONS: Cough was the commonest finding among these MDRTB patients, with 179 (92.75%) of them presenting with cough, followed by chest X-ray consolidation in 156 patients (80.83%) and history of previous TB treatment in 151 patients (78.24%). Cigarette smoking, HIV positivity, and low CD4 counts were significantly associated with MDRTB mortality, p values of 0.034, 0.044, and 0.048, respectively. Fever on the other hand was at the borderline with p value of 0.059. We conclude that cigarette smoking and HIV status are significant risk factors for mortality among MDRTB patients. HIV screening should continually be emphasized among patients and the general community for early ARTs initiation. Based on the results from our study, policy makers and public health personnel should consider addressing tobacco cessation as part of national TB control strategy.
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spelling pubmed-55418082017-08-14 Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania Mollel, Edson W. Chilongola, Jaffu O. J Trop Med Research Article PROBLEM: Factors related to MDRTB mortality in Tanzania have not been adequately explored and reported. OBJECTIVES: To determine demographic, clinical, radiographic, and laboratory factors associated with MDRTB mortality in a Tanzanian TB Referral Hospital. METHODOLOGY: This was a cross-sectional study with 193 participants. Demographic, clinical, laboratory, and radiological data were collected, and their associations with mortality among MDRTB patients were determined. RESULTS AND CONCLUSIONS: Cough was the commonest finding among these MDRTB patients, with 179 (92.75%) of them presenting with cough, followed by chest X-ray consolidation in 156 patients (80.83%) and history of previous TB treatment in 151 patients (78.24%). Cigarette smoking, HIV positivity, and low CD4 counts were significantly associated with MDRTB mortality, p values of 0.034, 0.044, and 0.048, respectively. Fever on the other hand was at the borderline with p value of 0.059. We conclude that cigarette smoking and HIV status are significant risk factors for mortality among MDRTB patients. HIV screening should continually be emphasized among patients and the general community for early ARTs initiation. Based on the results from our study, policy makers and public health personnel should consider addressing tobacco cessation as part of national TB control strategy. Hindawi 2017 2017-07-20 /pmc/articles/PMC5541808/ /pubmed/28808447 http://dx.doi.org/10.1155/2017/9241238 Text en Copyright © 2017 Edson W. Mollel and Jaffu O. Chilongola. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mollel, Edson W.
Chilongola, Jaffu O.
Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania
title Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania
title_full Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania
title_fullStr Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania
title_full_unstemmed Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania
title_short Predictors for Mortality among Multidrug-Resistant Tuberculosis Patients in Tanzania
title_sort predictors for mortality among multidrug-resistant tuberculosis patients in tanzania
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541808/
https://www.ncbi.nlm.nih.gov/pubmed/28808447
http://dx.doi.org/10.1155/2017/9241238
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