Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis

We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and markedly increased lysosome numbers per cell. This enhanced lysosomal sequestration of chemotherapeutics, away from their intracellular targe...

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Detalles Bibliográficos
Autores principales: Zhitomirsky, Benny, Assaraf, Yehuda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542171/
https://www.ncbi.nlm.nih.gov/pubmed/28187461
http://dx.doi.org/10.18632/oncotarget.15155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542171/
https://www.ncbi.nlm.nih.gov/pubmed/28187461
http://dx.doi.org/10.18632/oncotarget.15155

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