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Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis

We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and markedly increased lysosome numbers per cell. This enhanced lysosomal sequestration of chemotherapeutics, away from their intracellular targe...

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Detalles Bibliográficos
Autores principales:	Zhitomirsky, Benny, Assaraf, Yehuda G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542171/ https://www.ncbi.nlm.nih.gov/pubmed/28187461 http://dx.doi.org/10.18632/oncotarget.15155

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