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Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis

Previous epidemiological research suggests polymorphisms in long non-coding RNA (lncRNA) H19 are associated with an increased risk of cancer, but the results are inconsistent. We therefore conducted a meta-analysis to more accurately determine the association between lncRNA H19 polymorphisms and can...

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Autores principales: Li, Xue-Feng, Yin, Xin-Hai, Cai, Jun-Wei, Wang, Ming-Ju, Zeng, Yu-Qin, Li, Min, Niu, Yu-Ming, Shen, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542173/
https://www.ncbi.nlm.nih.gov/pubmed/28404885
http://dx.doi.org/10.18632/oncotarget.16658
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author Li, Xue-Feng
Yin, Xin-Hai
Cai, Jun-Wei
Wang, Ming-Ju
Zeng, Yu-Qin
Li, Min
Niu, Yu-Ming
Shen, Ming
author_facet Li, Xue-Feng
Yin, Xin-Hai
Cai, Jun-Wei
Wang, Ming-Ju
Zeng, Yu-Qin
Li, Min
Niu, Yu-Ming
Shen, Ming
author_sort Li, Xue-Feng
collection PubMed
description Previous epidemiological research suggests polymorphisms in long non-coding RNA (lncRNA) H19 are associated with an increased risk of cancer, but the results are inconsistent. We therefore conducted a meta-analysis to more accurately determine the association between lncRNA H19 polymorphisms and cancer risk. The PubMed, Embase, and Science Citation Index online databases were searched and 11 relevant studies involving a total of 33,209 participants were identified. Odds ratios (ORs) and corresponding 95% confidence interval (CIs) from these studies were used to detect associations between H19 polymorphisms and cancer risk using five genetic models. The pooled result suggested that the rs2839698 G>A polymorphism was associated with digestive cancer risk in all five models. Moreover, a protective effect against cancer development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations. No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk. In summary, the rs2839698 G>A and rs2107425 C>T polymorphisms in lncRNA H19 may therefore play opposing roles during cancer development, and their effects may vary depending on cancer type and patient ethnicity.
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spelling pubmed-55421732017-08-07 Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis Li, Xue-Feng Yin, Xin-Hai Cai, Jun-Wei Wang, Ming-Ju Zeng, Yu-Qin Li, Min Niu, Yu-Ming Shen, Ming Oncotarget Research Paper Previous epidemiological research suggests polymorphisms in long non-coding RNA (lncRNA) H19 are associated with an increased risk of cancer, but the results are inconsistent. We therefore conducted a meta-analysis to more accurately determine the association between lncRNA H19 polymorphisms and cancer risk. The PubMed, Embase, and Science Citation Index online databases were searched and 11 relevant studies involving a total of 33,209 participants were identified. Odds ratios (ORs) and corresponding 95% confidence interval (CIs) from these studies were used to detect associations between H19 polymorphisms and cancer risk using five genetic models. The pooled result suggested that the rs2839698 G>A polymorphism was associated with digestive cancer risk in all five models. Moreover, a protective effect against cancer development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations. No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk. In summary, the rs2839698 G>A and rs2107425 C>T polymorphisms in lncRNA H19 may therefore play opposing roles during cancer development, and their effects may vary depending on cancer type and patient ethnicity. Impact Journals LLC 2017-03-29 /pmc/articles/PMC5542173/ /pubmed/28404885 http://dx.doi.org/10.18632/oncotarget.16658 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Li, Xue-Feng
Yin, Xin-Hai
Cai, Jun-Wei
Wang, Ming-Ju
Zeng, Yu-Qin
Li, Min
Niu, Yu-Ming
Shen, Ming
Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis
title Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis
title_full Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis
title_fullStr Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis
title_full_unstemmed Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis
title_short Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis
title_sort significant association between lncrna h19 polymorphisms and cancer susceptibility: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542173/
https://www.ncbi.nlm.nih.gov/pubmed/28404885
http://dx.doi.org/10.18632/oncotarget.16658
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