Prognostic value of transglutaminase 2 in non-small cell lung cancer patients

Transglutaminase 2 (TG2) plays important roles in cell survival and cancer progression. In this study, we examined TG2 expression in specimen of 194 patients diagnosed with non-small cell lung cancer (NSCLC), and found that the TG2 gene expression was significantly higher in lung cancer tissues as c...

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Autores principales: Chihong, Zhu, Yutian, Ling, Danying, Wan, Ruibin, Jiang, Huaying, Sheng, Linhui, Gu, Jianguo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542209/
https://www.ncbi.nlm.nih.gov/pubmed/28715877
http://dx.doi.org/10.18632/oncotarget.17374
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author Chihong, Zhu
Yutian, Ling
Danying, Wan
Ruibin, Jiang
Huaying, Sheng
Linhui, Gu
Jianguo, Feng
author_facet Chihong, Zhu
Yutian, Ling
Danying, Wan
Ruibin, Jiang
Huaying, Sheng
Linhui, Gu
Jianguo, Feng
author_sort Chihong, Zhu
collection PubMed
description Transglutaminase 2 (TG2) plays important roles in cell survival and cancer progression. In this study, we examined TG2 expression in specimen of 194 patients diagnosed with non-small cell lung cancer (NSCLC), and found that the TG2 gene expression was significantly higher in lung cancer tissues as compared to paired incisal marginal tissues or normal tissues. Our data revealed that patients with lower level of TG2 expression detected in cancer tissues had longer disease free survival and overall survival as compared to the patients with higher TG2 expression. We also found that TG2 expression level correlated to NSCLC recurrence. These results suggest a potential prognosis impact of TG2 for NSCLC patients.
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spelling pubmed-55422092017-08-07 Prognostic value of transglutaminase 2 in non-small cell lung cancer patients Chihong, Zhu Yutian, Ling Danying, Wan Ruibin, Jiang Huaying, Sheng Linhui, Gu Jianguo, Feng Oncotarget Research Paper Transglutaminase 2 (TG2) plays important roles in cell survival and cancer progression. In this study, we examined TG2 expression in specimen of 194 patients diagnosed with non-small cell lung cancer (NSCLC), and found that the TG2 gene expression was significantly higher in lung cancer tissues as compared to paired incisal marginal tissues or normal tissues. Our data revealed that patients with lower level of TG2 expression detected in cancer tissues had longer disease free survival and overall survival as compared to the patients with higher TG2 expression. We also found that TG2 expression level correlated to NSCLC recurrence. These results suggest a potential prognosis impact of TG2 for NSCLC patients. Impact Journals LLC 2017-04-24 /pmc/articles/PMC5542209/ /pubmed/28715877 http://dx.doi.org/10.18632/oncotarget.17374 Text en Copyright: © 2017 Chihong et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Chihong, Zhu
Yutian, Ling
Danying, Wan
Ruibin, Jiang
Huaying, Sheng
Linhui, Gu
Jianguo, Feng
Prognostic value of transglutaminase 2 in non-small cell lung cancer patients
title Prognostic value of transglutaminase 2 in non-small cell lung cancer patients
title_full Prognostic value of transglutaminase 2 in non-small cell lung cancer patients
title_fullStr Prognostic value of transglutaminase 2 in non-small cell lung cancer patients
title_full_unstemmed Prognostic value of transglutaminase 2 in non-small cell lung cancer patients
title_short Prognostic value of transglutaminase 2 in non-small cell lung cancer patients
title_sort prognostic value of transglutaminase 2 in non-small cell lung cancer patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542209/
https://www.ncbi.nlm.nih.gov/pubmed/28715877
http://dx.doi.org/10.18632/oncotarget.17374
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