Cargando…

Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance

Trastuzumab is an antibody-based therapy drug targeting HER2-overexpressing tumors. While it has been proven to be very successful initially, most patients eventually develop resistance to trastuzumab. The mechanism of drug resistance is not well understood. Identifying pathways that mediate trastuz...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Wenhu, Chang, Jinxia, Liu, Mingwei, Yuan, Jiangbei, Zhang, Jinqiang, Qin, Jun, Xia, Xuefeng, Wang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542228/ https://www.ncbi.nlm.nih.gov/pubmed/28507275 http://dx.doi.org/10.18632/oncotarget.17415

Ejemplares similares

Label-Free Quantitative Proteomics Combined with Biological Validation Reveals Activation of Wnt/β-Catenin Pathway Contributing to Trastuzumab Resistance in Gastric Cancer
por: Liu, Wenhu, et al.
Publicado: (2018)

Global metabolomic profiling of trastuzumab resistant gastric cancer cells reveals major metabolic pathways and metabolic signatures based on UHPLC-Q exactive-MS/MS
por: Liu, Wenhu, et al.
Publicado: (2019)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Proteomics of autism and Alzheimer’s mouse models reveal common alterations in mTOR signaling pathway
por: Mencer, Shira, et al.
Publicado: (2021)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Metabolic pathways underlying GATA6 regulating Trastuzumab resistance in Gastric Cancer cells based on untargeted metabolomics
por: Chang, Jinxia, et al.
Publicado: (2020)

Proteomic Analysis Shows Synthetic Oleanane Triterpenoid Binds to mTOR
por: Yore, Mark M., et al.
Publicado: (2011)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
por: Spormann, Luise, et al.
Publicado: (2020)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
por: Rodrik-Outmezguine, Vanessa S., et al.
Publicado: (2016)

Control of mTOR Signaling by Ubiquitin
por: Jiang, Yao, et al.
Publicado: (2019)

mTOR and lysosome regulation
por: Puertollano, Rosa
Publicado: (2014)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Targeting glutaminase and mTOR
por: Tanaka, Kazuhiro, et al.
Publicado: (2015)

mTOR in cerebrovascular disease
por: Van Skike, Candice E., et al.
Publicado: (2019)

mTOR and Tumor Cachexia
por: Duval, Adrian P., et al.
Publicado: (2018)

Double agent mTOR
por: Danzer, Steve C.
Publicado: (2019)

mTOR in Human Diseases
por: Dormond, Olivier
Publicado: (2019)

mTOR Contributes to the Proteome Diversity through Transcriptome-Wide Alternative Splicing
por: Cheng, Sze, et al.
Publicado: (2022)

mTOR regulates GPVI-mediated platelet activation
por: Wang, Longsheng, et al.
Publicado: (2021)

Characterization of mTOR Activity and Metabolic Profile in Pediatric Rhabdomyosarcoma
por: Felkai, Luca, et al.
Publicado: (2020)

Commentary: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
por: Renna, Maurizio
Publicado: (2016)

mTOR: An attractive therapeutic target for osteosarcoma?
por: Ding, Liu, et al.
Publicado: (2016)

Experimental Approaches in Delineating mTOR Signaling
por: Qian, Jiayi, et al.
Publicado: (2020)

mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging
por: Węsierska-Gądek, Józefa
Publicado: (2010)

Plasticity and mTOR: Towards Restoration of Impaired Synaptic Plasticity in mTOR-Related Neurogenetic Disorders
por: Gipson, Tanjala T., et al.
Publicado: (2012)

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors
por: Hassan, Burhan, et al.
Publicado: (2014)

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer
por: De Martino, Maria Cristina, et al.
Publicado: (2019)

AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
por: Umanah, George K. E., et al.
Publicado: (2022)

mTOR co-targeting strategies for head and neck cancer therapy
por: Wang, Zhiyong, et al.
Publicado: (2017)

Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival
por: Smithson, Laura J., et al.
Publicado: (2016)

Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway
por: Čokić, Vladan P., et al.
Publicado: (2015)

The Roles of Post-Translational Modifications on mTOR Signaling
por: Yin, Shasha, et al.
Publicado: (2021)

Modulation of mTOR and epigenetic pathways as therapeutics in gallbladder cancer
por: Yang, Dong, et al.
Publicado: (2020)

Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues
por: Lee, Hojung
Publicado: (2017)

Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas
por: Snijders, Antoine M., et al.
Publicado: (2015)

mTOR-sensitive translation: Cleared fog reveals more trees
por: Masvidal, Laia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nivke1j3hhjcto0h69kd159mvq