Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma

Juvenile xanthogranuloma (JXG) is a rare histiocytic disorder that is usually benign and self-limiting. We present a case of atypical, aggressive JXG harboring a novel mitogen-activated protein kinase (MAPK) pathway mutation in the MAPK1 gene, which encodes mitogen-activated protein kinase 1 or extr...

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Detalles Bibliográficos
Autores principales: Chakraborty, Rikhia, Hampton, Oliver A., Abhyankar, Harshal, Zinn, Daniel J., Grimes, Amanda, Skull, Brooks, Eckstein, Olive, Mahmood, Nadia, Wheeler, David A., Lopez-Terrada, Dolores, Peters, Tricia L., Hicks, John M., Elghetany, Tarek, Krance, Robert, Poulikakos, Poulikos I., Merad, Miriam, McClain, Kenneth L., Allen, Carl E., Parsons, Donald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542249/
https://www.ncbi.nlm.nih.gov/pubmed/28512266
http://dx.doi.org/10.18632/oncotarget.17521

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