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Oncogenic MNK signalling regulates the metastasis suppressor NDRG1

The protein N-myc down-regulated gene 1 (NDRG1) represses tumour metastasis. It is phosphorylated at several sites by serum and glucocorticoid-regulated kinase 1 (SGK1). Here we show that NDRG1 is also regulated by the oncogenic MAP kinase-interacting kinase (MNK) pathway, a target for cancer therap...

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Detalles Bibliográficos
Autores principales:	Tian, Shuye, Wang, Xuemin, Proud, Christopher G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542254/ https://www.ncbi.nlm.nih.gov/pubmed/28545025 http://dx.doi.org/10.18632/oncotarget.17555

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