Cargando…

MicroRNA-145 down-regulates mucin 5AC to alleviate airway remodeling and targets EGFR to inhibit cytokine expression

This study aims to explore how microRNA-145 (miR-145) affects airway remodeling and cytokine expression by targeting epidermal growth factor receptor (EGFR) to regulate mucin 5AC (MUC5AC). Mice alveolar epithelial cells (AECs) were divided into a control, blank, miR-145 mimics, mimic control, miR-14...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Zhe, Dai, Ling-Ling, Wang, Xi, Jia, Liu-Qun, Jing, Xiao-Gang, Li, Peng-Fei, Liu, Meng, Wang, Huan, An, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542269/ https://www.ncbi.nlm.nih.gov/pubmed/28564633 http://dx.doi.org/10.18632/oncotarget.17933

Ejemplares similares

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity
por: Evans, Christopher M., et al.
Publicado: (2015)

Telmisartan mitigates lipopolysaccharide (LPS)-induced production of mucin 5AC (MUC5AC) through increasing suppressor of cytokine signaling 1 (SOCS1)
por: Chen, Ling, et al.
Publicado: (2021)

Mucins MUC5AC and MUC5B in the Airways: MUCing around Together
por: Kesimer, Mehmet
Publicado: (2022)

Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin
por: Rada, Balázs, et al.
Publicado: (2010)

Eupatilin alleviates airway remodeling via regulating phenotype plasticity of airway smooth muscle cells
por: Li, Yanqi, et al.
Publicado: (2020)

MUC5AC mucin release from human airways in vitro: effects of indomethacin and Bay X1005.
por: Roger, P, et al.
Publicado: (2001)

Effect of Chrysin on Gene Expression and Production of MUC5AC Mucin from Cultured Airway Epithelial Cells
por: Shin, Hyun-Dae, et al.
Publicado: (2012)

Characterization of the human mucin 5AC promoter and its regulation by the histone acetyltransferase P300
por: Xu, Shiyao, et al.
Publicado: (2019)

Bee Venom Prevents Mucin 5AC Production through Inhibition of AKT and SPDEF Activation in Airway Epithelia Cells
por: Kim, Sanga, et al.
Publicado: (2021)

Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy
por: Chen, Leying, et al.
Publicado: (2022)

LncRNA AC136007.2 alleviates cerebral ischemic-reperfusion injury by suppressing autophagy
por: Liu, Na, et al.
Publicado: (2021)

Reineckia carnea Alleviates the Production of Inflammatory Cytokines and MUC5AC in Rats with Chronic Obstructive Pulmonary Disease
por: Liu, Wei, et al.
Publicado: (2022)

Airway smooth muscle inflammation is regulated by microRNA‐145 in COPD
por: O'Leary, Lawrence, et al.
Publicado: (2016)

Effects of Scutellarin on MUC5AC Mucin Production Induced by Human Neutrophil Elastase or Interleukin 13 on Airway Epithelial Cells
por: Jiang, De-Peng, et al.
Publicado: (2011)

Effects of Lupenone, Lupeol, and Taraxerol Derived from Adenophora triphylla on the Gene Expression and Production of Airway MUC5AC Mucin
por: Yoon, Yong Pill, et al.
Publicado: (2015)

Type IV collagen reduces mucin 5AC secretion in three-dimensional cultured human primary airway epithelial cells
por: Ito, Yuho, et al.
Publicado: (2019)

Down-regulation of lncRNA MALAT1 alleviates vascular lesion and vascular remodeling of rats with hypertension
por: Xue, Yu-Zeng, et al.
Publicado: (2019)

Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice
por: Wang, I-Jong, et al.
Publicado: (2009)

Role of Th17 Cytokines in Airway Remodeling in Asthma and Therapy Perspectives
por: Margelidon-Cozzolino, Victor, et al.
Publicado: (2022)

Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin
por: Lee, Hyun Jae, et al.
Publicado: (2014)

Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells
por: Yoon, Yong Pill, et al.
Publicado: (2014)

Regulation of the Gene Expression of Airway MUC5AC Mucin through NF-(κ)B Signaling Pathway by Artesunate, an Antimalarial Agent
por: Kim, Kyung-il, et al.
Publicado: (2023)

Annexin-A1-Derived Peptide Ac2-26 Suppresses Allergic Airway Inflammation and Remodelling in Mice
por: Ferreira, Tatiana Paula Teixeira, et al.
Publicado: (2022)

Strategies for measuring airway mucus and mucins
por: Atanasova, Kalina R., et al.
Publicado: (2019)

Muc5ac Mucin Expression During Rat Skin Development
por: Ferretti, V., et al.
Publicado: (2015)

Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2
por: Lin, Xiao-Ping, et al.
Publicado: (2018)

Role of Abl in airway hyperresponsiveness and airway remodeling
por: Cleary, Rachel A, et al.
Publicado: (2013)

Airway Remodeling in Asthma
por: Hough, Kenneth P., et al.
Publicado: (2020)

MicroRNA-145 engineered bone marrow-derived mesenchymal stem cells alleviated erectile dysfunction in aged rats
por: Liu, Qiwei, et al.
Publicado: (2019)

Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats
por: Lin, Li, et al.
Publicado: (2019)

ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma
por: Huang, Chuanjun, et al.
Publicado: (2018)

Effects of microRNA-19b on airway remodeling, airway inflammation and degree of oxidative stress by targeting TSLP through the Stat3 signaling pathway in a mouse model of asthma
por: Ye, Ling, et al.
Publicado: (2017)

EGFR Immunoexpression in Malignant Serous and Mucinous Ovarian Tumors
por: CÎRSTEA, A.E., et al.
Publicado: (2018)

Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma
por: Dwertmann Rico, Sebastian, et al.
Publicado: (2022)

Immunohistochemical detection of MUC5AC and MUC5B mucins in ferrets
por: Meyerholz, David K., et al.
Publicado: (2023)

Plasma Bile Acid Profiling and Modulation of Secreted Mucin 5AC in Cholangiocarcinoma
por: Danese, Elisa, et al.
Publicado: (2023)

Selective Regulation of the Airway Mucin MUC5B in the Distal Airway
por: Kim, Eunjoo, et al.
Publicado: (2019)

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin
por: Ermund, Anna, et al.
Publicado: (2017)

Use of Recombinant Mucin Glycoprotein to Assess the Interaction of the Gastric Pathogen Helicobacter pylori with the Secreted Human Mucin MUC5AC
por: Dunne, Ciara, et al.
Publicado: (2017)

Evaluating the efficacy and cardiotoxicity of EGFR-TKI AC0010 with a novel multifunctional biosensor
por: Jiang, Deming, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4m905euqupbg12j8g9a2t5pfe3