Cargando…
Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series
BACKGROUND: Due to the extremely rare incidence, data of clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumors (GISTs) are limited. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of mesenteric GISTs. PATIEN...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542287/ https://www.ncbi.nlm.nih.gov/pubmed/28147326 http://dx.doi.org/10.18632/oncotarget.14880 |
_version_ | 1783254961038032896 |
---|---|
author | Feng, Fan Feng, Bin Liu, Shushang Liu, Zhen Xu, Guanghui Guo, Man Lian, Xiao Fan, Daiming Zhang, Hongwei |
author_facet | Feng, Fan Feng, Bin Liu, Shushang Liu, Zhen Xu, Guanghui Guo, Man Lian, Xiao Fan, Daiming Zhang, Hongwei |
author_sort | Feng, Fan |
collection | PubMed |
description | BACKGROUND: Due to the extremely rare incidence, data of clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumors (GISTs) are limited. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of mesenteric GISTs. PATIENTS AND METHODS: Mesenteric GISTs cases were obtained from our center and from case reports and clinical series extracted from MEDLINE. Clinicopathological features and survivals were analyzed. RESULTS: A total of 114 mesenteric GISTs were enrolled in present study. The most common symptom was abdominal pain (20/72, 27.8%), followed by abdominal mass (13/72, 18.1%) and distention (9/72, 12.5%). Most tumors exceeded 10 cm in diameter (71/112, 63.4%), exceeded 5/50HPF in mitotic index (50/85, 58.8%), and were high risk (82/90, 91.1%). The five-year disease free survival (DFS) and disease specific survival (DSS) was 57.7% and 60.1%, respectively. Tumor size and mitotic index were associated with DFS and DSS. The distribution of tumor size, histological type, mitotic index and NIH risk category were significantly different between mesenteric and gastric GISTs. Prognosis of mesenteric GISTs was worse than that of gastric GISTs. However, multivariate analysis showed that location was not an independent prognostic factor for mesenteric and gastric GISTs. CONCLUSIONS: Most mesenteric GISTs exceeded 10 cm in diameter, exceeded 5/50HPF in mitotic index and were high risk. Mesenteric GISTs differed significantly from gastric GISTs in respect to clinicopathologic features. Mitotic index and tumor size were prognostic factors for mesenteric GISTs. The prognosis were comparable between mesenteric and gastric GISTs. |
format | Online Article Text |
id | pubmed-5542287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55422872017-08-07 Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series Feng, Fan Feng, Bin Liu, Shushang Liu, Zhen Xu, Guanghui Guo, Man Lian, Xiao Fan, Daiming Zhang, Hongwei Oncotarget Clinical Research Paper BACKGROUND: Due to the extremely rare incidence, data of clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumors (GISTs) are limited. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of mesenteric GISTs. PATIENTS AND METHODS: Mesenteric GISTs cases were obtained from our center and from case reports and clinical series extracted from MEDLINE. Clinicopathological features and survivals were analyzed. RESULTS: A total of 114 mesenteric GISTs were enrolled in present study. The most common symptom was abdominal pain (20/72, 27.8%), followed by abdominal mass (13/72, 18.1%) and distention (9/72, 12.5%). Most tumors exceeded 10 cm in diameter (71/112, 63.4%), exceeded 5/50HPF in mitotic index (50/85, 58.8%), and were high risk (82/90, 91.1%). The five-year disease free survival (DFS) and disease specific survival (DSS) was 57.7% and 60.1%, respectively. Tumor size and mitotic index were associated with DFS and DSS. The distribution of tumor size, histological type, mitotic index and NIH risk category were significantly different between mesenteric and gastric GISTs. Prognosis of mesenteric GISTs was worse than that of gastric GISTs. However, multivariate analysis showed that location was not an independent prognostic factor for mesenteric and gastric GISTs. CONCLUSIONS: Most mesenteric GISTs exceeded 10 cm in diameter, exceeded 5/50HPF in mitotic index and were high risk. Mesenteric GISTs differed significantly from gastric GISTs in respect to clinicopathologic features. Mitotic index and tumor size were prognostic factors for mesenteric GISTs. The prognosis were comparable between mesenteric and gastric GISTs. Impact Journals LLC 2017-01-28 /pmc/articles/PMC5542287/ /pubmed/28147326 http://dx.doi.org/10.18632/oncotarget.14880 Text en Copyright: © 2017 Feng et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Clinical Research Paper Feng, Fan Feng, Bin Liu, Shushang Liu, Zhen Xu, Guanghui Guo, Man Lian, Xiao Fan, Daiming Zhang, Hongwei Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series |
title | Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series |
title_full | Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series |
title_fullStr | Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series |
title_full_unstemmed | Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series |
title_short | Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series |
title_sort | clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542287/ https://www.ncbi.nlm.nih.gov/pubmed/28147326 http://dx.doi.org/10.18632/oncotarget.14880 |
work_keys_str_mv | AT fengfan clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT fengbin clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT liushushang clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT liuzhen clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT xuguanghui clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT guoman clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT lianxiao clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT fandaiming clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries AT zhanghongwei clinicopathologicalfeaturesandprognosisofmesentericgastrointestinalstromaltumorevaluationofapooledcaseseries |