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Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

In the last several decades, there have been significant advances in anticancer therapy. However, the development of resistance to cancer drugs and the lack of specificity related to actively dividing cells leading to toxic side effects have undermined these achievements. As a result, there is consi...

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Detalles Bibliográficos
Autores principales: Deslouches, Berthony, Di, Y. Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542299/
https://www.ncbi.nlm.nih.gov/pubmed/28422728
http://dx.doi.org/10.18632/oncotarget.16743
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author Deslouches, Berthony
Di, Y. Peter
author_facet Deslouches, Berthony
Di, Y. Peter
author_sort Deslouches, Berthony
collection PubMed
description In the last several decades, there have been significant advances in anticancer therapy. However, the development of resistance to cancer drugs and the lack of specificity related to actively dividing cells leading to toxic side effects have undermined these achievements. As a result, there is considerable interest in alternative drugs with novel antitumor mechanisms. In addition to the recent approach using immunotherapy, an effective but much cheaper therapeutic option of pharmaceutical drugs would still provide the best choice for cancer patients as the first line treatment. Ribosomally synthesized cationic antimicrobial peptides (AMPs) or host defense peptides (HDP) display broad-spectrum activity against bacteria based on electrostatic interactions with negatively charged lipids on the bacterial surface. Because of increased proportions of phosphatidylserine (negatively charged) on the surface of cancer cells compared to normal cells, cationic amphipathic peptides could be an effective source of anticancer agents that are both selective and refractory to current resistance mechanisms. We reviewed herein the prospect for AMP application to cancer treatment, with a focus on modes of action of cationic AMPs.
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spelling pubmed-55422992017-08-07 Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications Deslouches, Berthony Di, Y. Peter Oncotarget Review In the last several decades, there have been significant advances in anticancer therapy. However, the development of resistance to cancer drugs and the lack of specificity related to actively dividing cells leading to toxic side effects have undermined these achievements. As a result, there is considerable interest in alternative drugs with novel antitumor mechanisms. In addition to the recent approach using immunotherapy, an effective but much cheaper therapeutic option of pharmaceutical drugs would still provide the best choice for cancer patients as the first line treatment. Ribosomally synthesized cationic antimicrobial peptides (AMPs) or host defense peptides (HDP) display broad-spectrum activity against bacteria based on electrostatic interactions with negatively charged lipids on the bacterial surface. Because of increased proportions of phosphatidylserine (negatively charged) on the surface of cancer cells compared to normal cells, cationic amphipathic peptides could be an effective source of anticancer agents that are both selective and refractory to current resistance mechanisms. We reviewed herein the prospect for AMP application to cancer treatment, with a focus on modes of action of cationic AMPs. Impact Journals LLC 2017-03-31 /pmc/articles/PMC5542299/ /pubmed/28422728 http://dx.doi.org/10.18632/oncotarget.16743 Text en Copyright: © 2017 Deslouches and Di http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Deslouches, Berthony
Di, Y. Peter
Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
title Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
title_full Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
title_fullStr Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
title_full_unstemmed Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
title_short Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
title_sort antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542299/
https://www.ncbi.nlm.nih.gov/pubmed/28422728
http://dx.doi.org/10.18632/oncotarget.16743
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