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Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity
Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542301/ https://www.ncbi.nlm.nih.gov/pubmed/28445146 http://dx.doi.org/10.18632/oncotarget.16944 |
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author | Koleini, Navid Kardami, Elissavet |
author_facet | Koleini, Navid Kardami, Elissavet |
author_sort | Koleini, Navid |
collection | PubMed |
description | Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive picture has yet to emerge. Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having detrimental effects for the cell. Autophagic cell death has been described, and has been proposed to contribute to Dox-cardiotoxicity. Additionally, mitophagy, autophagic removal of damaged mitochondria, is affected by Dox in a manner contributing to toxicity. Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes. |
format | Online Article Text |
id | pubmed-5542301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55423012017-08-07 Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity Koleini, Navid Kardami, Elissavet Oncotarget Review Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. Severe side effects such as cardiotoxicity, however, limit Dox application. Mechanisms by which Dox promotes cardiac damage and cardiomyocyte cell death have been investigated extensively, but a definitive picture has yet to emerge. Autophagy, regarded generally as a protective mechanism that maintains cell viability by recycling unwanted and damaged cellular constituents, is nevertheless subject to dysregulation having detrimental effects for the cell. Autophagic cell death has been described, and has been proposed to contribute to Dox-cardiotoxicity. Additionally, mitophagy, autophagic removal of damaged mitochondria, is affected by Dox in a manner contributing to toxicity. Here we will review Dox-induced cardiotoxicity and cell death in the broad context of the autophagy and mitophagy processes. Impact Journals LLC 2017-04-07 /pmc/articles/PMC5542301/ /pubmed/28445146 http://dx.doi.org/10.18632/oncotarget.16944 Text en Copyright: © 2017 Koleini and Kardami http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Koleini, Navid Kardami, Elissavet Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity |
title | Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity |
title_full | Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity |
title_fullStr | Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity |
title_full_unstemmed | Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity |
title_short | Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity |
title_sort | autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542301/ https://www.ncbi.nlm.nih.gov/pubmed/28445146 http://dx.doi.org/10.18632/oncotarget.16944 |
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