Hypoxia inducible factors in hepatocellular carcinoma

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summa...

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Detalles Bibliográficos
Autores principales: Chen, Chu, Lou, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542303/
https://www.ncbi.nlm.nih.gov/pubmed/28493839
http://dx.doi.org/10.18632/oncotarget.17358
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author Chen, Chu
Lou, Tao
author_facet Chen, Chu
Lou, Tao
author_sort Chen, Chu
collection PubMed
description Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summarize the expression, function and target genes of hypoxia inducible factors in hepatocellular carcinoma. We also highlight the recent progress in hypoxia-targeted therapeutic strategies in hepatocellular carcinoma and discuss further the future efforts for the study of hypoxia and/or hypoxia inducible factors in this deadly disease.
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spelling pubmed-55423032017-08-07 Hypoxia inducible factors in hepatocellular carcinoma Chen, Chu Lou, Tao Oncotarget Review Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summarize the expression, function and target genes of hypoxia inducible factors in hepatocellular carcinoma. We also highlight the recent progress in hypoxia-targeted therapeutic strategies in hepatocellular carcinoma and discuss further the future efforts for the study of hypoxia and/or hypoxia inducible factors in this deadly disease. Impact Journals LLC 2017-04-21 /pmc/articles/PMC5542303/ /pubmed/28493839 http://dx.doi.org/10.18632/oncotarget.17358 Text en Copyright: © 2017 Chen and Lou http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Chen, Chu
Lou, Tao
Hypoxia inducible factors in hepatocellular carcinoma
title Hypoxia inducible factors in hepatocellular carcinoma
title_full Hypoxia inducible factors in hepatocellular carcinoma
title_fullStr Hypoxia inducible factors in hepatocellular carcinoma
title_full_unstemmed Hypoxia inducible factors in hepatocellular carcinoma
title_short Hypoxia inducible factors in hepatocellular carcinoma
title_sort hypoxia inducible factors in hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542303/
https://www.ncbi.nlm.nih.gov/pubmed/28493839
http://dx.doi.org/10.18632/oncotarget.17358
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