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EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency

Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and proliferate. If the cells are infected ex vivo, they are transformed into continuously proliferating lymphoblastoid cell lines (LCLs) that carry EBV DNA as extra-chromosomal episomes, express 9 latency-associated E...

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Detalles Bibliográficos
Autores principales:	Styles, Christine T., Bazot, Quentin, Parker, Gillian A., White, Robert E., Paschos, Kostas, Allday, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542390/ https://www.ncbi.nlm.nih.gov/pubmed/28771465 http://dx.doi.org/10.1371/journal.pbio.2001992

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