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Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases
Allosteric targeting is progressively gaining ground as a strategy in drug design. Its success, however, depends on our knowledge of the investigated system. In the case of the papain-like cysteine peptidase cathepsin K, a major obstacle in our understanding of allostery is represented by the lack o...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542433/ https://www.ncbi.nlm.nih.gov/pubmed/28771551 http://dx.doi.org/10.1371/journal.pone.0182387 |