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Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

Legionella pneumophila is a Gram-negative, flagellated bacterium that survives in phagocytes and causes Legionnaires’ disease. Upon infection of mammalian macrophages, cytosolic flagellin triggers the activation of Naip/NLRC4 inflammasome, which culminates in pyroptosis and restriction of bacterial...

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Detalles Bibliográficos
Autores principales:	Mascarenhas, Danielle P. A., Cerqueira, Daiane M., Pereira, Marcelo S. F., Castanheira, Fernanda V. S., Fernandes, Talita D., Manin, Graziele Z., Cunha, Larissa D., Zamboni, Dario S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542441/ https://www.ncbi.nlm.nih.gov/pubmed/28771586 http://dx.doi.org/10.1371/journal.ppat.1006502

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