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Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis

BACKGROUND: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association b...

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Autores principales: Yamada, Atsuo, Niikura, Ryota, Maki, Koutarou, Nakamura, Masanao, Watabe, Hirotsugu, Fujishiro, Mitsuhiro, Oka, Shiro, Fujimori, Shunji, Nakajima, Atsushi, Ohmiya, Naoki, Matsumoto, Takayuki, Tanaka, Shinji, Koike, Kazuhiko, Sakamoto, Choitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542471/
https://www.ncbi.nlm.nih.gov/pubmed/28771618
http://dx.doi.org/10.1371/journal.pone.0182586
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author Yamada, Atsuo
Niikura, Ryota
Maki, Koutarou
Nakamura, Masanao
Watabe, Hirotsugu
Fujishiro, Mitsuhiro
Oka, Shiro
Fujimori, Shunji
Nakajima, Atsushi
Ohmiya, Naoki
Matsumoto, Takayuki
Tanaka, Shinji
Koike, Kazuhiko
Sakamoto, Choitsu
author_facet Yamada, Atsuo
Niikura, Ryota
Maki, Koutarou
Nakamura, Masanao
Watabe, Hirotsugu
Fujishiro, Mitsuhiro
Oka, Shiro
Fujimori, Shunji
Nakajima, Atsushi
Ohmiya, Naoki
Matsumoto, Takayuki
Tanaka, Shinji
Koike, Kazuhiko
Sakamoto, Choitsu
author_sort Yamada, Atsuo
collection PubMed
description BACKGROUND: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. METHODS: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. RESULTS: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. CONCLUSION: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs.
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spelling pubmed-55424712017-08-12 Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis Yamada, Atsuo Niikura, Ryota Maki, Koutarou Nakamura, Masanao Watabe, Hirotsugu Fujishiro, Mitsuhiro Oka, Shiro Fujimori, Shunji Nakajima, Atsushi Ohmiya, Naoki Matsumoto, Takayuki Tanaka, Shinji Koike, Kazuhiko Sakamoto, Choitsu PLoS One Research Article BACKGROUND: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. METHODS: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. RESULTS: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. CONCLUSION: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs. Public Library of Science 2017-08-03 /pmc/articles/PMC5542471/ /pubmed/28771618 http://dx.doi.org/10.1371/journal.pone.0182586 Text en © 2017 Yamada et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yamada, Atsuo
Niikura, Ryota
Maki, Koutarou
Nakamura, Masanao
Watabe, Hirotsugu
Fujishiro, Mitsuhiro
Oka, Shiro
Fujimori, Shunji
Nakajima, Atsushi
Ohmiya, Naoki
Matsumoto, Takayuki
Tanaka, Shinji
Koike, Kazuhiko
Sakamoto, Choitsu
Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis
title Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis
title_full Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis
title_fullStr Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis
title_full_unstemmed Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis
title_short Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis
title_sort proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: a propensity-matched analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542471/
https://www.ncbi.nlm.nih.gov/pubmed/28771618
http://dx.doi.org/10.1371/journal.pone.0182586
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