Cargando…
Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis
BACKGROUND: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association b...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542471/ https://www.ncbi.nlm.nih.gov/pubmed/28771618 http://dx.doi.org/10.1371/journal.pone.0182586 |
_version_ | 1783254997859827712 |
---|---|
author | Yamada, Atsuo Niikura, Ryota Maki, Koutarou Nakamura, Masanao Watabe, Hirotsugu Fujishiro, Mitsuhiro Oka, Shiro Fujimori, Shunji Nakajima, Atsushi Ohmiya, Naoki Matsumoto, Takayuki Tanaka, Shinji Koike, Kazuhiko Sakamoto, Choitsu |
author_facet | Yamada, Atsuo Niikura, Ryota Maki, Koutarou Nakamura, Masanao Watabe, Hirotsugu Fujishiro, Mitsuhiro Oka, Shiro Fujimori, Shunji Nakajima, Atsushi Ohmiya, Naoki Matsumoto, Takayuki Tanaka, Shinji Koike, Kazuhiko Sakamoto, Choitsu |
author_sort | Yamada, Atsuo |
collection | PubMed |
description | BACKGROUND: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. METHODS: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. RESULTS: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. CONCLUSION: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs. |
format | Online Article Text |
id | pubmed-5542471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55424712017-08-12 Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis Yamada, Atsuo Niikura, Ryota Maki, Koutarou Nakamura, Masanao Watabe, Hirotsugu Fujishiro, Mitsuhiro Oka, Shiro Fujimori, Shunji Nakajima, Atsushi Ohmiya, Naoki Matsumoto, Takayuki Tanaka, Shinji Koike, Kazuhiko Sakamoto, Choitsu PLoS One Research Article BACKGROUND: Previous studies have reported that the suppression of acid secretion by using proton pump inhibitors (PPIs) results in dysbiosis of the small-bowel microbiota, leading to exacerbated small-bowel injuries, including erosions and ulcers. This study was designed to assess the association between PPI therapy and small-bowel lesions after adjustment for the differences in baseline characteristics between users and non-users of PPIs. METHODS: We retrospectively studied patients suspected to be suffering from small-bowel diseases, who underwent capsule endoscopy between 2010 and 2013. We used propensity matching to adjust for the differences in baseline characteristics between users and non-users of PPIs. The outcomes included the prevalence of small-bowel lesions: erosion, ulcer, angioectasia, varices, and tumor. RESULTS: We selected 327 patient pairs for analysis after propensity matching, and found no significant differences in the prevalence of small-bowel injuries, including erosions and ulcers, between users and non-users of PPIs. Two subgroup analyses of the effect of the type of PPI and the effect of PPI therapy in users and non-users of nonsteroidal anti-inflammatory drugs indicated no significant differences in the prevalence of small-bowel injuries in these two groups. CONCLUSION: PPI therapy did not increase the prevalence of small-bowel injury, regardless of the type of PPI used and the use of nonsteroidal anti-inflammatory drugs. Public Library of Science 2017-08-03 /pmc/articles/PMC5542471/ /pubmed/28771618 http://dx.doi.org/10.1371/journal.pone.0182586 Text en © 2017 Yamada et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yamada, Atsuo Niikura, Ryota Maki, Koutarou Nakamura, Masanao Watabe, Hirotsugu Fujishiro, Mitsuhiro Oka, Shiro Fujimori, Shunji Nakajima, Atsushi Ohmiya, Naoki Matsumoto, Takayuki Tanaka, Shinji Koike, Kazuhiko Sakamoto, Choitsu Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis |
title | Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis |
title_full | Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis |
title_fullStr | Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis |
title_full_unstemmed | Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis |
title_short | Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis |
title_sort | proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: a propensity-matched analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542471/ https://www.ncbi.nlm.nih.gov/pubmed/28771618 http://dx.doi.org/10.1371/journal.pone.0182586 |
work_keys_str_mv | AT yamadaatsuo protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT niikuraryota protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT makikoutarou protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT nakamuramasanao protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT watabehirotsugu protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT fujishiromitsuhiro protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT okashiro protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT fujimorishunji protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT nakajimaatsushi protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT ohmiyanaoki protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT matsumototakayuki protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT tanakashinji protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT koikekazuhiko protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis AT sakamotochoitsu protonpumpinhibitortherapydidnotincreasetheprevalenceofsmallbowelinjuryapropensitymatchedanalysis |