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The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome

BACKGROUND: P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breast cancer; one of the most prevalent malignancies worldwide, is still controversial. The current study is designed to evaluate the prognostic role of p53 mutation in breast cancer. METHODS:...

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Autores principales: Sadighi, Sanambar, Zokaasadi, Mohammad, Kasaeian, Amir, Maghsudi, Somaye, Jahanzad, Issa, Kamranzadeh Fumani, Hosein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542560/
https://www.ncbi.nlm.nih.gov/pubmed/28771563
http://dx.doi.org/10.1371/journal.pone.0182444
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author Sadighi, Sanambar
Zokaasadi, Mohammad
Kasaeian, Amir
Maghsudi, Somaye
Jahanzad, Issa
Kamranzadeh Fumani, Hosein
author_facet Sadighi, Sanambar
Zokaasadi, Mohammad
Kasaeian, Amir
Maghsudi, Somaye
Jahanzad, Issa
Kamranzadeh Fumani, Hosein
author_sort Sadighi, Sanambar
collection PubMed
description BACKGROUND: P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breast cancer; one of the most prevalent malignancies worldwide, is still controversial. The current study is designed to evaluate the prognostic role of p53 mutation in breast cancer. METHODS: one hundred and eighty five breast cancer patients were studied in this retrospective study. P53 mutation was detected by accumulation of p53 protein in the patients’ pathology samples. Immunohistochemistry (IHC) was used to detect the protein. The effect of p53 on the final outcome was assessed using Kaplan-Meier estimate of survival and compared by log-rank test. Prognostic effects analyzed by cox proportional hazard models. RESULTS: while the stage of the disease at presentation was not significantly different between p53 positive and negative patients, those with p53 mutation had a significantly poorer outcome in terms of overall and disease-free survival rates (OS and DFS). In a multivariate analysis hazard ratio of p53 mutation was about 5 and 3.8 for OS and DFS respectively. They also had a higher cumulative incidence of relapse. CONCLUSION: It seems that p53 mutation is an independent prognostic factor for breast cancer. Although larger prospective studies are needed to clarify the importance of such a conclusion.
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spelling pubmed-55425602017-08-12 The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome Sadighi, Sanambar Zokaasadi, Mohammad Kasaeian, Amir Maghsudi, Somaye Jahanzad, Issa Kamranzadeh Fumani, Hosein PLoS One Research Article BACKGROUND: P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breast cancer; one of the most prevalent malignancies worldwide, is still controversial. The current study is designed to evaluate the prognostic role of p53 mutation in breast cancer. METHODS: one hundred and eighty five breast cancer patients were studied in this retrospective study. P53 mutation was detected by accumulation of p53 protein in the patients’ pathology samples. Immunohistochemistry (IHC) was used to detect the protein. The effect of p53 on the final outcome was assessed using Kaplan-Meier estimate of survival and compared by log-rank test. Prognostic effects analyzed by cox proportional hazard models. RESULTS: while the stage of the disease at presentation was not significantly different between p53 positive and negative patients, those with p53 mutation had a significantly poorer outcome in terms of overall and disease-free survival rates (OS and DFS). In a multivariate analysis hazard ratio of p53 mutation was about 5 and 3.8 for OS and DFS respectively. They also had a higher cumulative incidence of relapse. CONCLUSION: It seems that p53 mutation is an independent prognostic factor for breast cancer. Although larger prospective studies are needed to clarify the importance of such a conclusion. Public Library of Science 2017-08-03 /pmc/articles/PMC5542560/ /pubmed/28771563 http://dx.doi.org/10.1371/journal.pone.0182444 Text en © 2017 Sadighi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sadighi, Sanambar
Zokaasadi, Mohammad
Kasaeian, Amir
Maghsudi, Somaye
Jahanzad, Issa
Kamranzadeh Fumani, Hosein
The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome
title The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome
title_full The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome
title_fullStr The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome
title_full_unstemmed The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome
title_short The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome
title_sort effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; a retrospective survey of outcome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542560/
https://www.ncbi.nlm.nih.gov/pubmed/28771563
http://dx.doi.org/10.1371/journal.pone.0182444
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