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The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome
BACKGROUND: P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breast cancer; one of the most prevalent malignancies worldwide, is still controversial. The current study is designed to evaluate the prognostic role of p53 mutation in breast cancer. METHODS:...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542560/ https://www.ncbi.nlm.nih.gov/pubmed/28771563 http://dx.doi.org/10.1371/journal.pone.0182444 |
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author | Sadighi, Sanambar Zokaasadi, Mohammad Kasaeian, Amir Maghsudi, Somaye Jahanzad, Issa Kamranzadeh Fumani, Hosein |
author_facet | Sadighi, Sanambar Zokaasadi, Mohammad Kasaeian, Amir Maghsudi, Somaye Jahanzad, Issa Kamranzadeh Fumani, Hosein |
author_sort | Sadighi, Sanambar |
collection | PubMed |
description | BACKGROUND: P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breast cancer; one of the most prevalent malignancies worldwide, is still controversial. The current study is designed to evaluate the prognostic role of p53 mutation in breast cancer. METHODS: one hundred and eighty five breast cancer patients were studied in this retrospective study. P53 mutation was detected by accumulation of p53 protein in the patients’ pathology samples. Immunohistochemistry (IHC) was used to detect the protein. The effect of p53 on the final outcome was assessed using Kaplan-Meier estimate of survival and compared by log-rank test. Prognostic effects analyzed by cox proportional hazard models. RESULTS: while the stage of the disease at presentation was not significantly different between p53 positive and negative patients, those with p53 mutation had a significantly poorer outcome in terms of overall and disease-free survival rates (OS and DFS). In a multivariate analysis hazard ratio of p53 mutation was about 5 and 3.8 for OS and DFS respectively. They also had a higher cumulative incidence of relapse. CONCLUSION: It seems that p53 mutation is an independent prognostic factor for breast cancer. Although larger prospective studies are needed to clarify the importance of such a conclusion. |
format | Online Article Text |
id | pubmed-5542560 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55425602017-08-12 The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome Sadighi, Sanambar Zokaasadi, Mohammad Kasaeian, Amir Maghsudi, Somaye Jahanzad, Issa Kamranzadeh Fumani, Hosein PLoS One Research Article BACKGROUND: P53; a tumor suppressor gene has known to have a role in a group of human cancers. Its role in breast cancer; one of the most prevalent malignancies worldwide, is still controversial. The current study is designed to evaluate the prognostic role of p53 mutation in breast cancer. METHODS: one hundred and eighty five breast cancer patients were studied in this retrospective study. P53 mutation was detected by accumulation of p53 protein in the patients’ pathology samples. Immunohistochemistry (IHC) was used to detect the protein. The effect of p53 on the final outcome was assessed using Kaplan-Meier estimate of survival and compared by log-rank test. Prognostic effects analyzed by cox proportional hazard models. RESULTS: while the stage of the disease at presentation was not significantly different between p53 positive and negative patients, those with p53 mutation had a significantly poorer outcome in terms of overall and disease-free survival rates (OS and DFS). In a multivariate analysis hazard ratio of p53 mutation was about 5 and 3.8 for OS and DFS respectively. They also had a higher cumulative incidence of relapse. CONCLUSION: It seems that p53 mutation is an independent prognostic factor for breast cancer. Although larger prospective studies are needed to clarify the importance of such a conclusion. Public Library of Science 2017-08-03 /pmc/articles/PMC5542560/ /pubmed/28771563 http://dx.doi.org/10.1371/journal.pone.0182444 Text en © 2017 Sadighi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sadighi, Sanambar Zokaasadi, Mohammad Kasaeian, Amir Maghsudi, Somaye Jahanzad, Issa Kamranzadeh Fumani, Hosein The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome |
title | The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome |
title_full | The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome |
title_fullStr | The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome |
title_full_unstemmed | The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome |
title_short | The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome |
title_sort | effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; a retrospective survey of outcome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542560/ https://www.ncbi.nlm.nih.gov/pubmed/28771563 http://dx.doi.org/10.1371/journal.pone.0182444 |
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