Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism

Heme oxygenase from Leptospira interrogans is an important virulence factor. During catalysis, redox equivalents are provided to this enzyme by the plastidic-type ferredoxin-NADP(+) reductase also found in L. interrogans. This process may have evolved to aid this bacterial pathogen to obtain heme-ir...

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Detalles Bibliográficos
Autores principales: Soldano, Anabel, Klinke, Sebastián, Otero, Lisandro H., Rivera, Mario, Catalano-Dupuy, Daniela L., Ceccarelli, Eduardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542595/
https://www.ncbi.nlm.nih.gov/pubmed/28771589
http://dx.doi.org/10.1371/journal.pone.0182535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542595/
https://www.ncbi.nlm.nih.gov/pubmed/28771589
http://dx.doi.org/10.1371/journal.pone.0182535

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