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Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6

Background: Cardiac fibroblasts, together with cardiomyocytes, occupy the majority of cells in the myocardium and are involved in myocardial remodeling. The lysophospholipid mediator sphigosine-1-phosphate (S1P) regulates functions of cardiovascular cells through multiple receptors including S1PR1–S...

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Detalles Bibliográficos
Autores principales:	Ohkura, Sei-ichiro, Usui, Soichiro, Takashima, Shin-ichiro, Takuwa, Noriko, Yoshioka, Kazuaki, Okamoto, Yasuo, Inagaki, Yutaka, Sugimoto, Naotoshi, Kitano, Teppei, Takamura, Masayuki, Wada, Takashi, Kaneko, Shuichi, Takuwa, Yoh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542600/ https://www.ncbi.nlm.nih.gov/pubmed/28771545 http://dx.doi.org/10.1371/journal.pone.0182329

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