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Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults

Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation. Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. Since UCP2 is...

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Autores principales: Heise, Verena, Zsoldos, Enikő, Suri, Sana, Sexton, Claire, Topiwala, Anya, Filippini, Nicola, Mahmood, Abda, Allan, Charlotte L., Singh-Manoux, Archana, Kivimäki, Mika, Mackay, Clare E., Ebmeier, Klaus P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542610/
https://www.ncbi.nlm.nih.gov/pubmed/28771482
http://dx.doi.org/10.1371/journal.pone.0181392
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author Heise, Verena
Zsoldos, Enikő
Suri, Sana
Sexton, Claire
Topiwala, Anya
Filippini, Nicola
Mahmood, Abda
Allan, Charlotte L.
Singh-Manoux, Archana
Kivimäki, Mika
Mackay, Clare E.
Ebmeier, Klaus P.
author_facet Heise, Verena
Zsoldos, Enikő
Suri, Sana
Sexton, Claire
Topiwala, Anya
Filippini, Nicola
Mahmood, Abda
Allan, Charlotte L.
Singh-Manoux, Archana
Kivimäki, Mika
Mackay, Clare E.
Ebmeier, Klaus P.
author_sort Heise, Verena
collection PubMed
description Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation. Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. Since UCP2 is expressed in several brain regions, we investigated in this study whether UCP2 polymorphisms might 1) affect occurrence of neurodegenerative or mental health disorders and 2) affect measures of brain structure and function. We used structural magnetic resonance imaging (MRI), diffusion-weighted MRI and resting-state functional MRI in the neuroimaging sub-study of the Whitehall II cohort. Data from 536 individuals aged 60 to 83 years were analyzed. No association of UCP2 polymorphisms with the occurrence of neurodegenerative disorders or grey and white matter structure or resting-state functional connectivity was observed. However, there was a significant effect on occurrence of mood disorders in men with the minor alleles of -866G>A (rs659366) and Ala55Val (rs660339)) being associated with increasing odds of lifetime occurrence of mood disorders in a dose dependent manner. This result was not accompanied by effects of UCP2 polymorphisms on brain structure and function, which might either indicate that the sample investigated here was too small and underpowered to find any significant effects, or that potential effects of UCP2 polymorphisms on the brain are too subtle to be picked up by any of the neuroimaging measures used.
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spelling pubmed-55426102017-08-12 Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults Heise, Verena Zsoldos, Enikő Suri, Sana Sexton, Claire Topiwala, Anya Filippini, Nicola Mahmood, Abda Allan, Charlotte L. Singh-Manoux, Archana Kivimäki, Mika Mackay, Clare E. Ebmeier, Klaus P. PLoS One Research Article Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation. Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. Since UCP2 is expressed in several brain regions, we investigated in this study whether UCP2 polymorphisms might 1) affect occurrence of neurodegenerative or mental health disorders and 2) affect measures of brain structure and function. We used structural magnetic resonance imaging (MRI), diffusion-weighted MRI and resting-state functional MRI in the neuroimaging sub-study of the Whitehall II cohort. Data from 536 individuals aged 60 to 83 years were analyzed. No association of UCP2 polymorphisms with the occurrence of neurodegenerative disorders or grey and white matter structure or resting-state functional connectivity was observed. However, there was a significant effect on occurrence of mood disorders in men with the minor alleles of -866G>A (rs659366) and Ala55Val (rs660339)) being associated with increasing odds of lifetime occurrence of mood disorders in a dose dependent manner. This result was not accompanied by effects of UCP2 polymorphisms on brain structure and function, which might either indicate that the sample investigated here was too small and underpowered to find any significant effects, or that potential effects of UCP2 polymorphisms on the brain are too subtle to be picked up by any of the neuroimaging measures used. Public Library of Science 2017-08-03 /pmc/articles/PMC5542610/ /pubmed/28771482 http://dx.doi.org/10.1371/journal.pone.0181392 Text en © 2017 Heise et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Heise, Verena
Zsoldos, Enikő
Suri, Sana
Sexton, Claire
Topiwala, Anya
Filippini, Nicola
Mahmood, Abda
Allan, Charlotte L.
Singh-Manoux, Archana
Kivimäki, Mika
Mackay, Clare E.
Ebmeier, Klaus P.
Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
title Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
title_full Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
title_fullStr Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
title_full_unstemmed Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
title_short Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
title_sort uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542610/
https://www.ncbi.nlm.nih.gov/pubmed/28771482
http://dx.doi.org/10.1371/journal.pone.0181392
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