ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals

N-methyl-D-aspartate receptor (NMDA-R) antagonists and nitric oxide inhibitors have shown promising efficacy in depression but commonly induce adverse events. To circumvent these, a more indirect disruption of the nitric oxide synthase/postsynaptic density protein 95 kDa complex at the NMDA-R has be...

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Detalles Bibliográficos
Autores principales: Tillmann, Sandra, Pereira, Vitor Silva, Liebenberg, Nico, Christensen, Anne Karina, Wegener, Gregers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542618/
https://www.ncbi.nlm.nih.gov/pubmed/28771575
http://dx.doi.org/10.1371/journal.pone.0182698

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