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Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress

Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that radiation responsiveness will be enhanced in cellular models with decreased mtDNA content, attributed to altered reactive oxygen species (RO...

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Detalles Bibliográficos
Autores principales:	van Gisbergen, Marike W., Voets, An M., Biemans, Rianne, Hoffmann, Roland F., Drittij-Reijnders, Marie-José, Haenen, Guido R. M. M., Heijink, Irene H., Rouschop, Kasper M. A., Dubois, Ludwig J., Lambin, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542624/ https://www.ncbi.nlm.nih.gov/pubmed/28771582 http://dx.doi.org/10.1371/journal.pone.0182508

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