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Potent Prearranged Positive Allosteric Modulators of the Glucagon‐like Peptide‐1 Receptor

Drugs that allosterically modulate G protein‐coupled receptor (GPCR) activity display higher specificity and may improve disease treatment. However, the rational design of compounds that target the allosteric site is difficult, as conformations required for receptor activation are poorly understood....

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Detalles Bibliográficos
Autores principales:	Jones, Ben J., Scopelliti, Rosario, Tomas, Alejandra, Bloom, Stephen R., Hodson, David J., Broichhagen, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542757/ https://www.ncbi.nlm.nih.gov/pubmed/28794944 http://dx.doi.org/10.1002/open.201700062

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