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Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis

The uridyl transferases TUT4 and TUT7 switch between two modes of activity that either promotes let-7 expression (monoU) or marks it for degradation (oligoU). Lin28 modulates the switch via recruitment of TUT4(7) to pre-let-7 in stem cells and human cancers. We found TUT4(7) utilize two multi-domain...

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Detalles Bibliográficos
Autores principales:	Faehnle, Christopher R., Walleshauser, Jack, Joshua-Tor, Leemor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542866/ https://www.ncbi.nlm.nih.gov/pubmed/28671666 http://dx.doi.org/10.1038/nsmb.3428

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